Article (Scientific journals)
Abnormal Thymocyte Subpopulations in Split Dose Irradiated C57bl/Ka Mice before the Onset of Lymphomas. Effects of Bone Marrow Grafting
Rongy, A. M.; Humblet, Chantal; Lelievre, P. et al.
1990In Thymus, 16 (1), p. 7-27
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Keywords :
thymocyte subpopulations; radiation-induced thymic lymphoma; preleukemic cells
Abstract :
[en] Fractionated whole-body X irradiation (4 x 1.75 Gy at weekly intervals) induces a high percentage of thymic lymphomas in C57BL/Ka mice. The present work reports the phenotypic alterations of thymocyte subpopulations during the preleukemic period: there were a decrease of CD4+ CD8+ cells and an increase of CD4- CD8- and CD4- CD8+ cells. Marrow grafting early after irradiation that prevents lymphoma development restores the thymocyte subpopulations. In many instances, transplantation of 'preleukemic thymocyte inoculate' gives rise to an active and long lasting repopulation of recipient thymuses. However in all cases, donor lymphomas can develop after inoculation of 'preleukemic thymocyte inoculate'.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Rongy, A. M.
Humblet, Chantal ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Lelievre, P.
Greimers, Roland ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Language :
English
Title :
Abnormal Thymocyte Subpopulations in Split Dose Irradiated C57bl/Ka Mice before the Onset of Lymphomas. Effects of Bone Marrow Grafting
Publication date :
August 1990
Journal title :
Thymus
ISSN :
0165-6090
Publisher :
Kluwer Academic Publishers, Netherlands
Volume :
16
Issue :
1
Pages :
7-27
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Belgian Foundation for Medical Scientific Research
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
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