ORBi: Kaux Jean-François - Tendon lesion and platelet-rich plasma (PRP) injection: rat model

Reference : Tendon lesion and platelet-rich plasma (PRP) injection: rat model


	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Human health sciences : Orthopedics, rehabilitation & sports medicine
	To cite this reference:	http://hdl.handle.net/2268/75573

Title :	Tendon lesion and platelet-rich plasma (PRP) injection: rat model
Language :	English
Author, co-author :	Kaux, Jean-François [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
	Drion, Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]
	Renouf, Julien [> >]
	Pascon, Frédéric [Université de Liège - ULg > Département Argenco : Secteur GEO3 > Géomécanique et géologie de l'ingénieur >]
	Libertiaux, Vincent [Université de Liège - ULg > Département Argenco : Secteur MS2F > Mécanique des solides >]
	Colige, Alain [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs >]
	Le Goff, Caroline [Université de Liège - ULg > > Chimie médicale >]
	Lambert, Charles [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs >]
	Nusgens, Betty [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
	Gothot, André [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]
	Cescotto, Serge [Université de Liège - ULg > Département Argenco : Secteur MS2F > Mécanique des solides >]
	Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
	Rickert, Markus [> >]
	Crielaard, Jean-Michel [Université de Liège - ULg > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques - Médecine physique et réadaptation fonctionnelle >]
Publication date :	3-Dec-2010
Main document title :	Annual Congress of the RBSPRM
On invitation :	No
Audience :	National
Event name :	Annual Congress of the RBSPRM
Event date :	4-5 december 2010
Event organizer :	Royal Belgian Society of Physical and Rehabilitation Medicine
Event place (city) :	Brussels
Event country :	Belgium
Keywords :	[en] platelet-rich plasma ; tendon ; healing
Abstract :	[en] Introduction: For a few years, the positive effect of platelets on the healing process of different tissues (skin, bones...) was demonstrated. In fact platelets contain lots of growth factors which can be release locally and enhance the healing process. Thus the aim of our experiment was to ascertain by an original mechanical measure whether the use of PRP was of interest for accelerating the healing process of rats’ Achilles tendons after surgical induced lesion. Methods: Ninety rats’ Achilles tendons were sectioned. Forty-two rats beneficed of a PRP injection in situ. After 5, 15 and 30 days, 15 rats of both groups were euthanized after tendon sampling which were immediately submitted to a biomechanical tensile test until tendon rupture, using an original method of measurement (“cryo-jaw”). Histological and biochemical analyses were made as well as a quantification of collagen with an original procedure (quantification of the “greys” on histological cross-sections). Results: Tendons in the PRP group were more resistant to rupture than those in the control group. Histological findings showed in this group an increase of collagen proliferation and better collagen fibres reorganization. However, we did not find any biochemical difference neither in term of encoding gene expression for type III collagen, matrix metalloprotease 9 and tenomodulin. Conclusion: Our animal study demonstrated that an injection of PRP could accelerate the tendons healing process and improve its quality.
Permalink :	http://hdl.handle.net/2268/75573
Commentary :	This lecture was awarded at the annual congress (2010, September 3rd) of the Royal Belgian Society of Physical and Rehabilitation Medicine. I do not have any objections to you using this presentation, but please remember that the material is copyrighted by my medical school, and that the intellectual property is recognised as being mine. Therefore, each and every single slide will have to be acknowledged in writing on the slide itself as being mine, and the medical school logo should be displayed (you can copy and paste it from the first slide).

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Tendon lesion and platelet-rich plasma (PRP) injection rat model - KAUX.pdf	No commentary	Author postprint	1.57 MB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5