Reference : Tendon lesion and platelet-rich plasma (PRP) injection: rat model
Scientific congresses and symposiums : Paper published in a book
Human health sciences : Orthopedics, rehabilitation & sports medicine
http://hdl.handle.net/2268/75573
Tendon lesion and platelet-rich plasma (PRP) injection: rat model
English
Kaux, Jean-François mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Drion, Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]
Renouf, Julien [> >]
Pascon, Frédéric [Université de Liège - ULg > Département Argenco : Secteur GEO3 > Géomécanique et géologie de l'ingénieur >]
Libertiaux, Vincent mailto [Université de Liège - ULg > Département Argenco : Secteur MS2F > Mécanique des solides >]
Colige, Alain [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs >]
Le Goff, Caroline [Université de Liège - ULg > > Chimie médicale >]
Lambert, Charles [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs >]
Nusgens, Betty [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Gothot, André [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]
Cescotto, Serge [Université de Liège - ULg > Département Argenco : Secteur MS2F > Mécanique des solides >]
Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Rickert, Markus [> >]
Crielaard, Jean-Michel [Université de Liège - ULg > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques - Médecine physique et réadaptation fonctionnelle >]
3-Dec-2010
Annual Congress of the RBSPRM
Yes
No
National
Annual Congress of the RBSPRM
4-5 december 2010
Royal Belgian Society of Physical and Rehabilitation Medicine
Brussels
Belgium
[en] platelet-rich plasma ; tendon ; healing
[en] Introduction: For a few years, the positive effect of platelets on the healing process of different tissues (skin, bones...) was demonstrated. In fact platelets contain lots of growth factors which can be release locally and enhance the healing process. Thus the aim of our experiment was to ascertain by an original mechanical measure whether the use of PRP was of interest for accelerating the healing process of rats’ Achilles tendons after surgical induced lesion.
Methods: Ninety rats’ Achilles tendons were sectioned. Forty-two rats beneficed of a PRP injection in situ. After 5, 15 and 30 days, 15 rats of both groups were euthanized after tendon sampling which were immediately submitted to a biomechanical tensile test until tendon rupture, using an original method of measurement (“cryo-jaw”). Histological and biochemical analyses were made as well as a quantification of collagen with an original procedure (quantification of the “greys” on histological cross-sections).
Results: Tendons in the PRP group were more resistant to rupture than those in the control group. Histological findings showed in this group an increase of collagen proliferation and better collagen fibres reorganization. However, we did not find any biochemical difference neither in term of encoding gene expression for type III collagen, matrix metalloprotease 9 and tenomodulin.
Conclusion: Our animal study demonstrated that an injection of PRP could accelerate the tendons healing process and improve its quality.
http://hdl.handle.net/2268/75573
This lecture was awarded at the annual congress (2010, September 3rd) of the Royal Belgian Society of Physical and Rehabilitation Medicine.

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