Osteochondral plate angiogenesis: A new treatment target in osteoarthritis.

[en] Healthy adult joint cartilage contains neither blood vessels nor nerves. Osteoarthritic cartilage, in contrast, may be invaded by blood vessels from the subchondral bone. The mechanisms underlying cartilage angiogenesis in osteoarthritis are unclear but may involve hypertrophic chondrocyte differentiation. Active research is under way to identify the factors involved in cartilage angiogenesis. Here, we discuss the pathophysiological mechanisms of osteoarthritic cartilage angiogenesis based on evidence from a systematic literature review of articles retrieved via PubMed and ISI Web of Knowledge. Our conclusions suggest new research perspectives and treatment options.

Disciplines :

Rheumatology

Author, co-author :

Pesesse, Laurence ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Sanchez, Christelle ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie

Language :

English

Title :

Osteochondral plate angiogenesis: A new treatment target in osteoarthritis.

Publication date :

2011

Journal title :

Joint Bone Spine

ISSN :

1297-319X

eISSN :

1778-7254

Publisher :

Elsevier Science, Paris, France

Volume :

Pages :

144-149

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 12 November 2010

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Bibliography

Clark J.M. The structure of vascular channels in the subchondral plate. J Anat 1990, 171:105-115.
Duncan H., Jundt J., Riddle J.M., et al. The tibial subchondral plate. A scanning electron microscopic study. J Bone Joint Surg Am 1987, 69:1212-1220.
Aigner T., Dudhia J. Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: a hypothesis. Ann Rheum Dis 1997, 56:287-291.
Li B., Marshall D., Roe M., et al. The electron microscope appearance of the subchondral bone plate in the human femoral head in osteoarthritis and osteoporosis. J Anat 1999, 195(Part 1):101-110.
Oegema T.R., Carpenter R.J., Hofmeister F., et al. The interaction of the zone of calcified cartilage and subchondral bone in osteoarthritis. Microsc Res Tech 1997, 37:324-332.
Rees J.A., Ali S.Y. Ultrastructural localisation of alkaline phosphatase activity in osteoarthritic human articular cartilage. Ann Rheum Dis 1988, 47:747-753.
Rucklidge G.J., Milne G., Robins S.P. Collagen type X: a component of the surface of normal human, pig, and rat articular cartilage. Biochem Biophys Res Commun 1996, 224:297-302.
Imhof H., Sulzbacher I., Grampp S., et al. Subchondral bone and cartilage disease-a rediscovered functional unit. Invest Radiol 2000, 35:581-588.
Lorenz H., Richter W. Osteoarthritis: cellular and molecular changes in degenerating cartilage. Prog Histochem Cytochem 2006, 40:135-163.
Pfander D., Swoboda B., Kirsch T. Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. Am J Pathol 2001, 159:1777-1783.
Pullig O., Weseloh G., Ronneberger D., et al. Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. Calcif Tissue Int 2000, 67:230-240.
Thambyah A., Broom N. On new bone formation in the pre-osteoarthritic joint. Osteoarthritis Cartilage 2009, 17:456-463.
Sanchez C., Msika P., Baudoin C., et al. Study of in vitro conditions promoting hypertrophic differenciation of osteoarthritic articular chondrocytes [abstract]. Osteoarthritis Cartilage 2007, 15 Suppl. C:109-110.
Sanchez C., Deberg M.A., Bellahcène A., et al. Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone. Arthritis Rheum 2008, 58:442-455.
Guevremont M., Martel-Pelletier J., Massicotte F., et al. Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage. J Bone Miner Res 2003, 18:1073-1081.
Sharif M., George E., Dieppe P.A. Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee. Arthritis Rheum 1995, 38:78-81.
Sanchez C., Deberg M.A., Piccardi N., et al. Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1 beta and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage 2005, 13:979-987.
Hiraki Y., Shukunami C. Chondromodulin-I as a novel cartilage-specific growth-modulating factor. Pediatr Nephrol 2000, 14:602-605.
Pfander D., Cramer T., Deuerling D., et al. Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage. Ann Rheum Dis 2000, 59:448-454.
Tombran-Tink J., Barnstable C.J. Osteoblasts and osteoclasts express PEDF. VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone. Biochem Biophys Res Commun 2004, 316:573-579.
Bellahcene A., Bonjean K., Fohr B., et al. Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Circ Res 2000, 86:885-891.
Cantatore F.P., Crivellato E., Nico B., et al. Osteocalcin is angiogenic in vivo. Cell Biol Int 2005, 29:583-585.
Ramoshebi L.N., Ripamonti U. Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-beta1. Anat Rec 2000, 259:97-107.
Walsh D.A., Pearson C.I. Angiogenesis in the pathogenesis of inflammatory joint and lung diseases. Arthritis Res 2001, 3:147-153.
Suri S., Gill S.E., Massena de Camin S., et al. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann Rheum Dis 2007, 66:1423-1428.
Brown R.A., Weiss J.B. Neovascularisation and its role in the osteoarthritic process. Ann Rheum Dis 1988, 47:881-885.
Haywood L., McWilliams D.F., Pearson C.I., et al. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum 2003, 48:2173-2177.
Clavel G., Bessis N., Boissier M.C. Recent data on the role for angiogenesis in rheumatoid arthritis. Joint Bone Spine 2003, 70:321-326.
Lehmann W., Edgar C.M., Wang K., et al. Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Bone 2005, 36:300-310.
Vincent T.L., McLean C.J., Full L.E., et al. FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage 2007, 15:752-763.
Brew C.J., Clegg P.D., Boot-Handford R.P., et al. Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy. Ann Rheum Dis 2010, 69:234-240.
Smith J.O., Oreffo R.O., Clarke N.M., et al. Changes in the antiangiogenic properties of articular cartilage in osteoarthritis. J Orthop Sci 2003, 8:849-857.
Cohen T., Gitay-Goren H., Sharon R., et al. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem 1995, 270:11322-11326.
Park J.E., Keller G.A., Ferrara N. Vascular endothelial growth factor (VEGF) isoforms - differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 1993, 4:1317-1326.
Crawford S.E., Stellmach V., Murphy-Ullrich J.E., et al. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 1998, 93:1159-1170.
Short S.M., Derrien A., Narsimhan R.P., et al. Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta(1) integrins. J Cell Biol 2005, 168:643-653.
Volpert O.V. Modulation of endothelial cell survival by an inhibitor of angiogenesis thrombospondin-1: a dynamic balance. Cancer Metast Rev 2000, 19:87-92.
Zhang X., Parangi S., Lawler J. Regulation of VEGF-induced vascular permeability and VEGFR2 signaling by thrombospondin-1. Modern Pathol 2009, 22:344a-a. [poster].
Canfield A.E., Schor A.M. Evidence that tenascin and thrombospondin-1 modulate sprouting of endothelial cells. J Cell Sci 1995, 108(Part 2):797-809.
Chevalier X., Groult N., Largetpiet B., et al. Tenascin distribution in articular-cartilage from normal subjects and from patients with osteoarthritis and rheumatoid-arthritis. Arthritis Rheum 1994, 37:1013-1022.
Moses M.A., Wiederschain D., Wu I., et al. Troponin I is present in human cartilage and inhibits angiogenesis. Proc Natl Acad Sci U S A 1999, 96:2645-2650.
Kern B.E., Balcom J.H., Antoniu B.A., et al. Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer. J Gastrointest Surg 2003, 7:961-968.
Shukunami C., Iyama K., Inoue H., et al. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation. Int J Dev Biol 1999, 43:39-49.
Hiraki Y., Tanaka H., Inoue H., et al. Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-i, which stimulates growth of cultured chondrocytes. Biochem Biophys Res Commun 1991, 175:971-977.
Funaki H., Sawaguchi S., Yaoeda K., et al. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye. Invest Ophthalmol Vis Sci 2001, 42:1193-1200.
Hayami T., Funaki H., Yaoeda K., et al. Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. J Rheumatol 2003, 30:2207-2217.
Papetti M., Herman I.M. Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 2002, 282:C947-C970.
Enomoto H., Inoki I., Komiya K., et al. Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol 2003, 162:171-181.
Murata M., Yudoh K., Masuko K. The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis?. Osteoarthritis Cartilage 2008, 16:279-286.
Hashimoto G., Inoki I., Fujii Y., et al. Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem 2002, 277:36288-36295.
Nisato R.E., Hosseini G., Sirrenberg C., et al. Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and alpha(v)beta3 are critical. Cancer Res 2005, 65:9377-9387.
Ichikawa Y., Ishikawa T., Momiyama N., et al. Matrilysin (MMP-7) degrades VE-cadherin and accelerates accumulation of beta-catenin in the nucleus of human umbilical vein endothelial cells. Oncol Rep 2006, 15:311-315.
Bini A., Wu D., Schnuer J., et al. Characterization of stromelysin 1 (MMP-3), matrilysin (MMP-7), and membrane type 1 matrix metalloproteinase (MT1-MMP) derived fibrin(ogen) fragments D-dimer and D-like monomer: NH2-terminal sequences of late-stage digest fragments. Biochemistry 1999, 38:13928-13936.
Levi E., Fridman R., Miao H.Q., et al. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. Proc Natl Acad Sci U S A 1996, 93:7069-7074.
Patterson B.C., Sang Q.A. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9). J Biol Chem 1997, 272:28823-28825.
O'Reilly M.S., Wiederschain D., Stetler-Stevenson W.G., et al. Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J Biol Chem 1999, 274:29568-29571.
Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 2003, 3:422-433.
Sandell L.J., Wang Z., Franz C., et al. Chondrostatin: a new inhibitor of angiogenesis, tumor invasion and osteoclast activity. J Bone Miner Res 2007, 22:T259.
Bonnet C.S., Walsh D.A. Osteoarthritis, angiogenesis and inflammation. Rheumatology 2005, 44:7-16.
Gerber H.P., Ferrara N. Angiogenesis and bone growth. Trends Cardiovasc Med 2000, 10:223-228.