Reference : Molecular Basis of Neuronal Biorhythms and Paroxysms
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/75021
Molecular Basis of Neuronal Biorhythms and Paroxysms
English
Grisar, Thierry mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique]
Lakaye, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Thomas, Elizabeth [> > > >]
Oct-1996
Archives of Physiology & Biochemistry
104
6
770-4
Yes (verified by ORBi)
International
1381-3455
[en] The molecular basis of the biorhythms are evoked in relation to cerebral EEG rhythms and paroxysms. Basic oscillatory phenomena have been well shown and modeled in systems such as the glycolytic pathway, the oscillations of cAMP in amoebas and rhythms of the intracellular cycline during mitosis. In excitable cells the intracellular calcium and cAMP oscillations exhibit a signalling system with many advantages. Thus the question arises: to what extent can the EEG paroxysms observed in epileptic syndrome be due to disturbances in such basic molecular pathways that underlie intracellular molecular oscillations? The usefulness of the absence-rat-model and the implication the T type Ca(2+)-channel of the thalamic nuclei in the pathophysiology of this epileptic syndrome are discussed.
http://hdl.handle.net/2268/75021

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