Reference : Wnt1 and BMP2: two factors recruiting multipotent neural crest progenitors isolated from...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/74733
Wnt1 and BMP2: two factors recruiting multipotent neural crest progenitors isolated from adult bone marrow
English
Glejzer, Aneta [Université de Liège - ULg > > GIGA - Neurosciences >]
Laudet, Emerence mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Leprince, Pierre mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Poulet, Christophe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Hennuy, Benoît mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme transcriptomique >]
Sommer, Lukas [> >]
Shakhova, Olga [> >]
Rogister, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Wislet-Gendebien, Sabine mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Jun-2011
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
68/12
2101-2114
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] Wnt1 ; BMP2 ; neural crest ; adult bone marrow
[en] Recent studies have shown that neural crestderived progenitor cells can be found in diverse mammalian tissues including tissues that were not previously shown to contain neural crest derivatives, such as bone marrow. The identification of those ‘‘new’’ neural crest-derived progenitor cells opens new strategies for developing autologous cell replacement therapies in regenerative medicine. However, their potential use is still a challenge as only few neural crest-derived progenitor cells were found in those new accessible locations. In this study, we developed a protocol, based on wnt1 and BMP2 effects, to enrich neural crest-derived cells from adult bone marrow. Those two factors are known to maintain and stimulate the proliferation of embryonic neural crest stem cells, however, their effects have never been characterized on neural crest cells isolated from adult tissues. Using multiple strategies from microarray to 2D-DIGE proteomic analyses, we characterized those recruited neural crest-derived cells, defining their identity and their differentiating abilities.
Giga-Neurosciences
Researchers ; Professionals
http://hdl.handle.net/2268/74733
Wislet-Gendebien S. and Rogister B have equally contributed to this paper.

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