Article (Scientific journals)
TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas.
Thielen, Caroline; Radermacher, Vincent; Trimeche, Mounir et al.
2008In Leukemia Research, 32 (9), p. 1431-8
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Keywords :
Adolescent; Adult; Aged; Aged, 80 and over; Chemokine CCL11/metabolism; Chemokine CCL17/metabolism; Chemokine CCL5/metabolism; Eosinophilia/metabolism/pathology; Eosinophils/pathology; Female; Humans; Immunoblastic Lymphadenopathy/metabolism/pathology; Immunoenzyme Techniques; Interleukin-5/metabolism; Lymphoma, T-Cell, Peripheral/metabolism/pathology; Male; Middle Aged; Prognosis
Abstract :
[en] The current study attempts to characterize the eosinophilia associated with T-cell lymphomas and to investigate its possible relationship with the secretion of eosinophil-stimulating factors by lymphoma cells and/or intra-tumoral surrounding cells. Paraffin-embedded specimens from 50 patients diagnosed with peripheral T-cell lymphomas, either unspecified (PTCL-U, n=30) or angioimmunoblastic (AITL, n=20) were morphologically assessed for intra-tumoral eosinophilia and analyzed by immunohistochemistry using specific antibodies directed against TARC, IL-5, RANTES, and eotaxin. The AITL and PTCL-U cases contained a mean of 147+/-41 and 102+/-37 eosinophils per 10 high power fields, respectively. Thirty-two of 47 cases (68%) showed IL-5-positive lymphoma cells while 15/50 (30%) tumors showed variable staining for TARC in scattered non-lymphoid cells with dendritic morphology. TARC and IL-5-positive cases possessed significantly more eosinophils. Our data indicate that IL-5 and TARC expression highly correlate with eosinophilia in T-cell lymphomas, suggesting that these chemokines are involved in the recruitment of eosinophils into the tumors.
Disciplines :
Oncology
Author, co-author :
Thielen, Caroline ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Radermacher, Vincent ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Trimeche, Mounir
Roufosse, Florence
Goldman, Michel
Boniver, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
de Leval, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques
Language :
English
Title :
TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas.
Publication date :
2008
Journal title :
Leukemia Research
ISSN :
0145-2126
Publisher :
Pergamon Press - An Imprint of Elsevier Science
Volume :
32
Issue :
9
Pages :
1431-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 March 2009

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