[en] In the late 1980s, a new hypervirulent and epidemic form of bovine viral diarrhoea virus (BVDV) infection appeared in North America. A similar but sporadic syndrome was later reported in Europe. To compare the pathogenic characters of the North American and European hypervirulent strains, we inoculated BVDV naive calves with BVDV strains isolated from haemorrhagic syndromes originating in Belgium, France and the USA. The experimental procedure comprised daily clinical examination and measurement of blood and virological parameters.The American BVD890/256 strain induced severe thrombocytopaenia, profuse diarrhoea and pneumonia in all calves, indicating that hypervirulent BVDV could be the primary infectious agent of pneumonia. Interestingly, a strong correlation was observed between the intense viraemia and a decreased platelet count. None of the European strains tested induced significant pathological signs, although isolated from cases presenting haemorrhagic syndrome.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hamers, Claude ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Unit of Immunology and Vaccinology / infectious diseases
Couvreur, Bernard; Veterinary and Agrochemical Research Centre (VAR) > Department of Virology
Dehan, Pierre ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Unit of Immunology and Vaccinology / infectious diseases
Letellier, Carine; Veterinary and Agrochemical Research Centre (VAR) > Department of Virology
Lewalle, P.; Institut J. Bordet > Laboratory of Experimental Haematology
Pastoret, Paul-Pierre ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Unit of Immunology and Vaccinology / infectious diseases
Kerkhofs, Pierre; Veterinary and Agrochemical Research Centre (VAR) > Department of Virology
Language :
English
Title :
Differences in Experimental Virulence of Bovine Viral Diarrhoea Viral Strains Isolated from Haemorrhagic Syndromes
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