Acanthosis nigricans associated with insulin resistance : pathophysiology and management.

[en] The association of acanthosis nigricans, skin tags, diabetes mellitus due to insulin resistance, and obesity in adolescents and young adults represents a well defined syndrome. Hyperandrogenism may also be present. The endocrine origin of this condition is beyond doubt. Insulin and insulin-like growth factor-1, and their receptors on keratinocytes are obviously involved in the complex regulations leading to the peculiar epidermal hyperplasia. This condition is unrelated to other types of acanthosis nigricans, including the congenital and the paraneoplastic types.Control of obesity contributes largely to reverse the whole process, essentially by reducing both insulin resistance and compensatory hyperinsulinemia. Several drugs including metformin, octreotide, retinoids and topical colecalciferol (vitamin D(3)) analogs are also beneficial in clearing acanthosis nigricans.

Disciplines :

Dermatology

Author, co-author :

Hermanns-Lê, Trinh ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Acanthosis nigricans associated with insulin resistance : pathophysiology and management.

Publication date :

2004

Journal title :

American Journal of Clinical Dermatology

ISSN :

1175-0561

eISSN :

1179-1888

Publisher :

Adis International, Auckland, New Zealand

Volume :

Issue :

Pages :

199-203

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 March 2009

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Scopus citations^®

136

Scopus citations^®
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132

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103

Bibliography

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