ORBi: Thielen Caroline - CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma

Reference : CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/74287

Title :	CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
Language :	English
Author, co-author :	Thielen, Caroline [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Bisig, Bettina [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
	Gofflot, Stéphanie [Université de Liège - ULg > > Génétique >]
	Herens, Christian [Université de Liège - ULg > > Génétique >]
	Fillet, Georges [Université de Liège - ULg > > Hématologie clinique >]
	Jamar, Mauricette [> >]
	Tassin, Françoise [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]
	Boniver, Jacques [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
	Drion, Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]
	de Leval, Laurence [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
Publication date :	2011
Journal title :	British Journal of Haematology
Publisher :	Blackwell Publishing
Volume :	152
Pages :	356-360
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0007-1048
e-ISSN :	1365-2141
City :	Oxford
Country :	United Kingdom
Keywords :	[en] anaplastic large cell lymphoma ; cell lines ; xenograft ; mouse model ; cytokines
Abstract :	[en] Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL, ALK+) has expanded, and beyond the common pattern most frequently encountered, several variants have been identified, including the lymphohistiocytic and the small cell patterns (Swerdlow et al, 2008). Only ten ALK+ ALCL cell lines are currently available, and most were derived from tumours demonstrating the common type morphology (Drexler & MacLeod, 2004). We have established a novel cell line (CHIC) from the cerebrospinal fluid of a 32-year-old man with relapsing/refractory ALK+ ALCL with a t(2;5)(p23;q35) translocation whose initial tumour exhibited lymphohistiocytic features. This cell line is now made available to the scientific community. In addition to multiple in vitro applications, the tumourigenic capacity of these cells represents a useful property for in vivo drug testing.
Research units :	Giga-Cancer
Funders :	Belgian National Fund for Scientific Research (F.N.R.S.) (convention 3.4582.05); Fondation Léon Fredericq; Centre Anticancéreux près l’Universite de Liège
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/74287
DOI :	10.1111/j.1365-2141.2010.08414.x
Other URL :	http://www.ncbi.nlm.nih.gov/pubmed/20955410
Commentary :	, by the , and by the

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