Reference : CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/74287
CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
English
Thielen, Caroline [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Bisig, Bettina [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Gofflot, Stéphanie [Université de Liège - ULg > > Génétique >]
Herens, Christian [Université de Liège - ULg > > Génétique >]
Fillet, Georges mailto [Université de Liège - ULg > > Hématologie clinique >]
Jamar, Mauricette [> >]
Tassin, Françoise [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]
Boniver, Jacques [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Drion, Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
2011
British Journal of Haematology
Blackwell Publishing
152
356-360
Yes (verified by ORBi)
International
0007-1048
1365-2141
Oxford
United Kingdom
[en] anaplastic large cell lymphoma ; cell lines ; xenograft ; mouse model ; cytokines
[en] Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL, ALK+) has expanded, and beyond the common pattern most frequently encountered, several variants have been identified, including the lymphohistiocytic
and the small cell patterns (Swerdlow et al, 2008). Only ten ALK+ ALCL cell lines are currently available, and most were derived from tumours demonstrating the common type morphology (Drexler & MacLeod, 2004). We have established a novel cell line (CHIC) from the cerebrospinal fluid of a 32-year-old man with relapsing/refractory ALK+ ALCL with a t(2;5)(p23;q35) translocation whose initial tumour exhibited lymphohistiocytic features. This cell line is now made available to the scientific community. In addition to multiple in vitro applications, the tumourigenic capacity of these cells represents a useful property for in vivo drug testing.
Giga-Cancer
Belgian National Fund for Scientific Research (F.N.R.S.) (convention 3.4582.05); Fondation Léon Fredericq; Centre Anticancéreux près l’Universite de Liège
Researchers ; Professionals
http://hdl.handle.net/2268/74287
10.1111/j.1365-2141.2010.08414.x
http://www.ncbi.nlm.nih.gov/pubmed/20955410
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