Article (Scientific journals)
CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
Thielen, Caroline; Bisig, Bettina; Gofflot, Stéphanie et al.
2011In British Journal of Haematology, 152, p. 356-360
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Keywords :
anaplastic large cell lymphoma; cell lines; xenograft; mouse model; cytokines
Abstract :
[en] Since the initial description of anaplastic large cell lymphoma (ALCL) as a proliferation of large CD30+ lymphoid cells, the morphological spectrum of ALCL positive for anaplastic lymphoma kinase (ALCL, ALK+) has expanded, and beyond the common pattern most frequently encountered, several variants have been identified, including the lymphohistiocytic and the small cell patterns (Swerdlow et al, 2008). Only ten ALK+ ALCL cell lines are currently available, and most were derived from tumours demonstrating the common type morphology (Drexler & MacLeod, 2004). We have established a novel cell line (CHIC) from the cerebrospinal fluid of a 32-year-old man with relapsing/refractory ALK+ ALCL with a t(2;5)(p23;q35) translocation whose initial tumour exhibited lymphohistiocytic features. This cell line is now made available to the scientific community. In addition to multiple in vitro applications, the tumourigenic capacity of these cells represents a useful property for in vivo drug testing.
Research center :
Giga-Cancer - ULiège
Disciplines :
Oncology
Author, co-author :
Thielen, Caroline ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bisig, Bettina ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Gofflot, Stéphanie ;  Université de Liège - ULiège > Génétique
Herens, Christian ;  Université de Liège - ULiège > Génétique
Fillet, Georges ;  Université de Liège - ULiège > Hématologie clinique
JAMAR, Mauricette 
Tassin, Françoise ;  Université de Liège - ULiège > Hématologie biologique et immuno hématologie
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Drion, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université
de Leval, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques
Language :
English
Title :
CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma
Publication date :
2011
Journal title :
British Journal of Haematology
ISSN :
0007-1048
eISSN :
1365-2141
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
152
Pages :
356-360
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
Fonds Léon Fredericq [BE]
Commentary :
, by the , and by the
Available on ORBi :
since 21 October 2010

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