Article (Scientific journals)
Determination of Meprobamate in Pharmaceutical Dosage Forms Also Containing Carbromal by Liquid Chromatography and Indirect Photometric Detection
Bechet, I.; Ceccato, Attilio; Hubert, Philippe et al.
1992In Journal of Pharmaceutical and Biomedical Analysis, 10 (10-12, Oct-Dec), p. 995-9
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Abstract :
[en] In a pharmaceutical form also containing carbromal, meprobamate could not be quantified selectively by classical methods described in pharmacopoeias due to a significant interference from carbromal. Consequently, reversed-phase HPLC methods have been developed to separate the two active ingredients using indirect photometric detection to visualize and determine meprobamate which has very poor chromophoric properties. Different parameters influencing the sensitivity of the indirect response, such as the nature of the highly absorbing compound added to the mobile phase (the marker) as well as the methanol content and the pH of this phase, have been studied. Two chromatographic systems containing benzoic acid or cinnamic acid as the marker, have been optimized and validated. Good linearity and reproducibility have been obtained with both systems but the cinnamic acid method has the advantage that meprobamate and carbromal can be determined simultaneously at 273 nm.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Bechet, I.
Ceccato, Attilio ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Hubert, Philippe  ;  Université de Liège - ULiège > Chimie analytique
Herné, Patrick ;  Université de Liège - ULiège > Département de pharmacie > Déontologie et législation pharmaceutiques
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Determination of Meprobamate in Pharmaceutical Dosage Forms Also Containing Carbromal by Liquid Chromatography and Indirect Photometric Detection
Publication date :
1992
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
10
Issue :
10-12, Oct-Dec
Pages :
995-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 March 2009

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