Reference : SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Sin...
Scientific journals : Article
Engineering, computing & technology : Electrical & electronics engineering
http://hdl.handle.net/2268/74015
SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Single-Stranded DNA Translocating Through a Nanopore
English
Leroux, Amandine mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Dép. d'électric., électron. et informat. (Inst.Montefiore) >]
Destiné, Jacques mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Electronique, microsystèmes, mesures et instrumentation >]
Vanderheyden, Benoît mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Electronique et microsystèmes >]
Gracheva, Maria mailto [Clarkson University > Department of Physics > > >]
Leburton, Jean-Pierre mailto [University of Illinois at Urbana-Champaign > Beckman Institute for Advanced Science and Technology and Department of Electrical Engineering > > >]
May-2010
IEEE Transactiones on Nanotechnology
9
3
322-329
Yes
International
[en] Circuit modeling ; DNA sequencing ; Solid-state nanopore ; Spice simulation
[en] In this paper, we describe a circuit-element model for the electric detection of biomolecules in translocation through a nanopore in a semiconductor-oxide-semiconductor (SOS) membrane. The biomolecules are simulated as a superposition of individual charges moving through the nanopore and inducing a charge variation on the membrane electrodes that is modeled as a current source. The SOS membrane is discretized into interconnected elementary circuit elements. The model is tested on the translocation of 11 base single-stranded C3AC7 DNA molecule, for which the electric signal shows good qualitative agreement with the multiscale device approach of Gracheva et al., while quantifying the low-pass filtering in the membrane. Overall, the model confirms the possibility of identifying the sequence of the DNA bases electrically.
http://hdl.handle.net/2268/74015

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