Reference : SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Sin...

	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Electrical & electronics engineering
	To cite this reference:	http://hdl.handle.net/2268/74015

Title :	SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Single-Stranded DNA Translocating Through a Nanopore
Language :	English
Author, co-author :	Leroux, Amandine [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Dép. d'électric., électron. et informat. (Inst.Montefiore) >]
	Destiné, Jacques [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Electronique, microsystèmes, mesures et instrumentation >]
	Vanderheyden, Benoît [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Electronique et microsystèmes >]
	Gracheva, Maria [Clarkson University > Department of Physics > > >]
	Leburton, Jean-Pierre [University of Illinois at Urbana-Champaign > Beckman Institute for Advanced Science and Technology and Department of Electrical Engineering > > >]
Publication date :	May-2010
Journal title :	IEEE Transactiones on Nanotechnology
Volume :	9
Issue/season :	3
Pages :	322-329
Peer reviewed :	Yes
Audience :	International
Keywords :	[en] Circuit modeling ; DNA sequencing ; Solid-state nanopore ; Spice simulation
Abstract :	[en] In this paper, we describe a circuit-element model for the electric detection of biomolecules in translocation through a nanopore in a semiconductor-oxide-semiconductor (SOS) membrane. The biomolecules are simulated as a superposition of individual charges moving through the nanopore and inducing a charge variation on the membrane electrodes that is modeled as a current source. The SOS membrane is discretized into interconnected elementary circuit elements. The model is tested on the translocation of 11 base single-stranded C3AC7 DNA molecule, for which the electric signal shows good qualitative agreement with the multiscale device approach of Gracheva et al., while quantifying the low-pass filtering in the membrane. Overall, the model confirms the possibility of identifying the sequence of the DNA bases electrically.
Permalink :	http://hdl.handle.net/2268/74015

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Open access Abstract.pdf Author postprint 18.06 kB View/Open

All documents in ORBi are protected by a user license.

 

© ULg Library Network |  Feedback |  ORBi legal notices

Dspace v1.5