Reference : Comparison and combination of spectroscopic techniques for the detection of counterfeit ...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/73587
Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines
English
[en] comparaison et combinaison de techniques spectroscopiques pour la détection de médicaments contrefaits
Sacré, Pierre-Yves mailto [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
Deconinck, Eric [> >]
De Beer, Thomas [> >]
Courselle, Patricia [> >]
Vancauwenberghe, Roy [> >]
Chiap, Patrice mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Crommen, Jacques mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
De Beer, Jacques [> >]
2010
Journal of Pharmaceutical & Biomedical Analysis
Elsevier Science
53
445-453
Yes (verified by ORBi)
International
0731-7085
Oxford
United Kingdom
[en] counterfeiting ; partial least squares ; IR-spectroscopy
[en] During this study, Fourier transform infrared spectroscopy (FT-IR), near infrared spectroscopy (NIR) and Raman spectroscopy were applied to 55 samples of counterfeit and imitations of Viagra® and 39 samples of counterfeit and imitations of Cialis®. The aim of the study was to investigate which of these techniques and associations of them were the best for discriminating genuine from counterfeit and imitation samples. Only the regions between 1800-400 cm-1 and 7000-4000 cm-1 were used for FT-IR and NIR spectroscopy respectively. Partial Least Square analysis has been used to allow the detection of counterfeit and imitation tablets. It is shown that for the Viagra® samples, the best results were provided by a combination of FT-IR and NIR spectroscopy. On the other hand, the best results for the Cialis® samples were provided by the combination of NIR and Raman spectroscopy (1400-1190 cm-1). These techniques permitted a clear discrimination between genuine and counterfeit or imitation samples but also the distinction of clusters among illegal samples. This might be interesting for forensic investigations by authorities.
http://hdl.handle.net/2268/73587

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Sacré et al, 2010.pdfPublisher postprint524.64 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.