Poster (Scientific congresses and symposiums)
Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines
Sacré, Pierre-Yves; Deconinck, Eric; De Beer, Thomas et al.
2010Drug Analysis 2010
 

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Keywords :
counterfeiting; partial least squares; IR-spectroscopy
Abstract :
[en] During this study, Fourier transform infrared spectroscopy (FT-IR), near infrared spectroscopy (NIR) and Raman spectroscopy were applied to 55 samples of counterfeit and imitations of Viagra® and 39 samples of counterfeit and imitations of Cialis®. The aim of the study was to investigate which of these techniques and associations of them were the best for discriminating genuine from counterfeit and imitation samples. Only the regions between 1800-400 cm-1 and 7000-4000 cm-1 were used for FT-IR and NIR spectroscopy respectively. Partial Least Square analysis has been used to allow the detection of counterfeit and imitation tablets. It is shown that for the Viagra® samples, the best results were provided by a combination of FT-IR and NIR spectroscopy. On the other hand, the best results for the Cialis® samples were provided by the combination of NIR and Raman spectroscopy (1400-1190 cm-1). These techniques permitted a clear discrimination between genuine and counterfeit or imitation samples but also the distinction of clusters among illegal samples. This might be interesting for forensic investigations by authorities.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Sacré, Pierre-Yves  ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Deconinck, Eric
De Beer, Thomas
Courselle, Patricia
Vancauwenberghe, Roy
Chiap, Patrice ;  Université de Liège - ULiège > Pharmacologie clinique
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
De Beer, Jacques
Language :
English
Title :
Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines
Alternative titles :
[en] comparaison et combinaison de techniques spectroscopiques pour la détection de médicaments contrefaits
Publication date :
23 September 2010
Event name :
Drug Analysis 2010
Event organizer :
Société Belge des Sciences Pharmaceutiques
Event place :
Anvers, Belgium
Event date :
21 septembre 2010 au 24 septembre 2010
Audience :
International
Available on ORBi :
since 07 October 2010

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