Reference : Genetic susceptibility in pituitary adenomas : from pathogenesis to clinical implications

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/71282

Title :	Genetic susceptibility in pituitary adenomas : from pathogenesis to clinical implications
Language :	English
Author, co-author :	Jaffrain-Rea, Marie-Lise [University of L’Aquila > >]
	Daly, Adrian [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
	Angelini, Mariolina [University of L’Aquila > >]
	Petrossians, Patrick [Université de Liège - ULg > > Endocrinologie clinique >]
	Bours, Vincent [Université de Liège - ULg > > Génétique >]
	Beckers, Albert [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Publication date :	2011
Journal title :	Expert Review of Endocrinology & Metabolism
Publisher :	Future Medicine Ltd
Audience :	International
ISSN :	1744-6651
Keywords :	[en] Pituitary adenoma ; familial isolated pituitary adenomas ; FIPA ; Aryl hydrocarbon receptor Interacting Protein ; AIP ; Multiple Endocrine Neoplasia type 1 ; MEN1 ; Carney complex ; McCune Albright syndrome ; hereditary neoplasia ; genetic screening
Abstract :	[en] Pituitary adenomas (PA) usually present sporadically, with a multifactorial pathogenesis including somatic mutational events in cancer-related genes. Genetic predisposition implies the presence of germline DNA alterations with a variety of impacts on pituitary cell biology, translating into a variable penetrance of the disease. Genetic causes must be considered in the presence of specific clinical settings, such as familial occurrence of PA, with or without extrapituitary diseases, and may also be suspected in young patients with macroadenomas. We <br />review the clinical implications of genetic predisposition, with special attention to Multiple Endocrine Neoplasia type 1 (MEN1), Carney’s complex (CNC) and FIPA (Familial Isolated Pituitary Adenoma), and the scenario of genetic screening in selected patients with an apparently sporadic disease is discussed.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/71282
	also: http://hdl.handle.net/2268/73444

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	Fulltext file(s): File Commentary Version Size Access Restricted access ExpReviews-JaffrainRea2011.pdf Publisher postprint 1.14 MB Request copy

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