Reference : Partially Segregated Neural Networks for Spatial and Contextual Memory in Virtual Nav...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/7334
Partially Segregated Neural Networks for Spatial and Contextual Memory in Virtual Navigation
English
Rauchs, G. [> > > >]
Orban, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Balteau, Evelyne [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Schmidt, Christina [Université de Liège - ULg > Centre de Recherches du Cyclotron > Neuropsychologie > > >]
Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André [Université de Liège - ULg > Centre de recherches du cyclotron -Département de chimie (sciences) > Chimie organique de synthèse - > > >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Peigneux, Philippe mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron Département des sciences cognitives > Département des sciences cognitives > >]
31-Jan-2008
Hippocampus
A Wiley Company
18
5
503-518
Yes (verified by ORBi)
International
1050-9631
1098-1063
[en] fMRI ; Hippocampus ; parahippocampal cortex
[fr] ecologically valid environment
[en] Finding our way in a previously learned, ecologically valid environment concurrently involves spatial and contextual cognitive operations. The former process accesses a cognitive map representing the spatial interactions between all paths in the environment. The latter accesses stored associations between landmark objects and their milieu. Here, we aimed at dissociating their neural basis in the context of memory-based virtual navigation. To do so, subjects freely explored a virtual town for 1 h, then were scanned using fMRI while retrieving their way between two locations, under four navigation conditions designed to probe separately or jointly the spatial and contextual memory components. Besides prominent commonalities found in a large hippocampo-neocortical network classically involved in topographical navigation, results yield evidence for a partial dissociation between the brain areas supporting spatial and contextual components of memory-based navigation. Performance-related analyses indicate that hippocampal activity mostly supports the spatial component, whereas parahippocampal activity primarily supports the contextual component. Additionally, the recruitment of contextual memory during navigation was associated with higher frontal, posterior parietal and lateral temporal activity. These results provide evidence for a partial segregation of the neural substrates of two crucial memory components in human navigation, whose combined involvement eventually leads to efficient navigation behavior within a learned environment. (c) 2008 Wiley-Liss, Inc.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fondation médicale Reine Elisabeth
http://hdl.handle.net/2268/7334
http://www3.interscience.wiley.com/journal/117904019/abstract

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Rauchs,Hippocampus,2008,MS.pdfAuthor preprint1.55 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.