Reference : Fluorinated tracers for imaging cancer with positron emission tomography
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/7319
Fluorinated tracers for imaging cancer with positron emission tomography
English
Couturier, Olivier [> > > >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Chatal, Jean-François [> > > >]
Vuillez, Jean-Philippe [> > > >]
Rigo, Pierre mailto [Université de Liège - ULg > Département des sciences de la motricité > Pathologie générale et médecine nucléaire >]
Hustinx, Roland mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine nucléaire]
Aug-2004
European Journal of Nuclear Medicine and Molecular Imaging
Springer
31
8
1182-1206
Yes (verified by ORBi)
International
1619-7070
New York
[en] Positron emission tomography ; Fluorinated tracers ; Cancer imaging
[en] 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine-18 is considered the ideal radioisotope for PET imaging owing to the low positron energy (0.64 MeV), which not only limits the dose rate to the patient but also results in a relatively short range of emission in tissue, thereby providing high-resolution images. Further, the 110-min physical half-life allows for high-yield radiosynthesis, transport from the production site to the imaging site and imaging protocols that may span hours, which permits dynamic studies and assessment of potentially fairly slow metabolic processes. The synthesis of fluorinated tracers as an alternative to FDG was initially tested using nucleophilic fluorination of the molecule, as performed when radiolabelling with iodine-124 or bromide-76. However, in addition to being long, with multiple steps, this procedure is not recommended for bioactive molecules containing reactive groups such as amine or thiol groups. Radiochemical yields are also often low. More recently, radiosynthesis from prosthetic group precursors, which allows easier radiolabelling of biomolecules, has led to the development of numerous fluorinated tracers. Given the wide availability of 18F, such tracers may well develop into important routine tracers. This article is a review of the literature concerning fluorinated radiotracers recently developed and under investigation for possible PET imaging in cancer patients. Two groups can be distinguished. The first includes "generalist" tracers, i.e. tracers amenable to use in a wide variety of tumours and indications, very similar in this respect to FDG. These are tracers for non-specific cell metabolism, such as protein synthesis, amino acid transport, nucleic acid synthesis or membrane component synthesis. The second group consists of "specific" tracers for receptor expression (i.e. oestrogens or somatostatin), cell hypoxia or bone metabolism.
http://hdl.handle.net/2268/7319
10.1007/s00259-004-1607-9
The original publication is available at www.springerlink.com/content/6jw773tg4bqa0pdm/?p=f72d4cee65074f95a805460e21b60927&pi=0

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