Reference : Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/73145
Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea
English
Tabatadze, Nino [ > > ]
Elias, Riad [ > > ]
Faure, Robert [ > > ]
Gerkens, Pascal [ > > ]
Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
Kemertelidze [ > > ]
Chea, Aun [ > > ]
Ollivier, Evelyne [ > > ]
Jan-2007
Chemical & Pharmaceutical Bulletin
55
1
102-105
Yes (verified by ORBi)
International
0009-2363
[en] triterpenoid ; saponin ; Cephalaria Gigantea
[en] Three new oleanane-type saponins, giganteosides L (1)(I), M (2) and N (3) along with eight known ones were isolated from the roots of Cephalaria gigantea. Their structures were established as 3-O-[-D-galactopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-oleanolic acid, 3-O-[-D-galactopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-hederagenin, 3-O-[-L-rhamnopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-hederagenin, resp., by means of spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Cytotoxic activity of monodesmosides was investigated in vitro using three cancer cell lines, namely, human non pigmented melanoma MEL-5 and human leukemia HL-60. Giganteosides D (4) and E (5) showed antiproliferative effect on human cell lines with IC50 values in the range 3.15-7.5 M.
Researchers
http://hdl.handle.net/2268/73145

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