ORBi: Duy Vo Thi Kim - Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases

Reference : Transcriptomic biomarkers of the response of hospitalized geriatric patients with infect...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Geriatrics Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/73085

Title :	Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases
Language :	English
Author, co-author :	Duy Vo, Thi Kim [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Research Institute for Life Sciences > Research Unit on Cellular Biology > >]
	Godard, Patrice [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Research Institute for Life Sciences > > >]
	de Saint-Hubert, Marie [Université Catholique de Louvain - UCL > University Hospital of Mont-Godinne > Geriatrics > >]
	Morrhaye, Gabriel [Université de Liège - ULg > > Centre d'immunologie >]
	Swine, Christian [Université Catholique de Louvain - UCL > University Hospital of Mont-Godinne > Geriatrics > >]
	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie - Embryologie >]
	Martens, Henri [Université de Liège - ULg > > Centre d'immunologie >]
	Debacq-Chainiaux, Florence [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Research Institute of Life Sciences > > >]
	Toussaint, Olivier [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Research Institute for Life Sciences > > >]
Publication date :	2010
Journal title :	Immunity & Ageing : I & A
Publisher :	BioMed Central
Volume :	17
Pages :	7-9
Audience :	International
e-ISSN :	1742-4933
Abstract :	[en] Background: Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of the infectious disease is poorly understood. Results: Herein the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of 28 healthy aged probands and 39 aged patients in acute phase of infectious disease (day 2-4 after hospitalization) or in convalescence phase (day 7-10). This study provides a list of 24 differentially abundant transcript species in the acute phase versus healthy aged. For instance, transcripts associated with inflammatory and anti-inflammatory reactions (TNFRSF1A, IL1R1, IL1R2, IL10RB) and with oxidative stress (HMOX1, GPX1, SOD2, PRDX6) were more abundant while those associated with T-cell functions (CD28, CD69, LCK) were less abundant in acute phase. The abundance of seven of these transcripts (CD28, CD69, LCK, CTSD, HMOX1, TNFRSF1A and PRDX6) was already known to be altered in healthy aged probands compared to healthy young ones and was further affected in aged patients in acute phase, compromising an efficient response. Conclusion: This work provides insights of the state of acute phase response to infections in elderly patients and could explain further the lack of appropriate response in the elderly compared to younger persons.
Funders :	Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Union Européenne = European Union - UE = EU
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/73085
DOI :	10.1186/1742-4933-7-9
Other URL :	http://www.immunityageing.com/content/7/1/9

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