Reference : Clostridium perfringens urease genes are plasmid-borne.
Scientific journals : Article
Life sciences : Food science
http://hdl.handle.net/2268/7302
Clostridium perfringens urease genes are plasmid-borne.
English
Dupuy, B. [ > > ]
Daube, Georges mailto [Université de Liège - ULg > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires >]
Popoff, M. R. [ > > ]
Cole, S. T. [ > > ]
1997
Infection and Immunity
American Society for Microbiology (ASM)
65
2313-2320
Yes (verified by ORBi)
International
0019-9567
1098-5522
Washington
DC
[en] Clostridium perfringens ; Urease gene
[en] Although many bacteria are ureolytic, and in some cases urease acts as a virulence factor, the urease
phenotype has not been analyzed in the anaerobic pathogen Clostridium perfringens. In this study, ;2% of C.
perfringens strains, representing the principal biotypes, were found to harbor the urease structural genes,
ureABC, and these were localized on large plasmids that often encode, in addition, the lethal « or i toxins or
the enterotoxin. This represents the first report of a plasmid-encoded urease in a gram-positive bacterium. The
C. perfringens enzyme was highly similar to the ureases of other bacteria and cross-reacted with antibodies
raised against the urease purified from Helicobacter pylori. Urease production was inhibited by urea and
induced under growth conditions where the availability of nitrogen sources was limiting. To date, this form of
regulation has been observed only for chromosomal ureABC genes.
Researchers ; Students
http://hdl.handle.net/2268/7302

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