Reference : Intensive care unit acquired infection and organ failure
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/72652
Intensive care unit acquired infection and organ failure
English
Damas, Pierre mailto [Université de Liège - ULg > > Soins intensifs >]
Ledoux, Didier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Nys, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs - Anesthésie et réanimation >]
Monchi, Mehran [Centre Hospitalier Universitaire de Liège - CHU > Anesthésie-Réanimation > Soins Intensifs Généraux > >]
Wiesen, Patricia mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Beauve, Benoît [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation >]
Preiser, Jean-Charles mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
May-2008
Intensive Care Medicine
Springer Verlag
34
856-864
Yes (verified by ORBi)
International
0342-4642
New York
NY
[en] OBJECTIVE: To assess the temporal relationship between ICU-acquired infection (IAI) and the prevalence and severity of organ dysfunction or failure (OD/F). DESIGN AND SETTING: Observational, single center study in a mixed intensive care unit of a university hospital. PATIENTS: We analyzed 1,191 patients hospitalized for more than 2 days during a 2-year observation period: 845 did not acquire IAI, 306 of whom had infection on admission (IOA); 346 did acquire IAI, 125 of whom had IOA. MEASUREMENTS AND RESULTS: The SOFA score was calculated daily, both SOFAmax, the sum of the worst OD/F during the ICU stay, and SOFApreinf, the sum of the worst OD/F existing before the occurrence of the first IAI. The SAPS II and SOFA score of the first 24 h were significantly higher in patients with than in those without IAI. SOFApreinf of IAI patients was also higher than the SOFAmax of patients without IAI both in patients with (12.1+/-4.6 vs. 8.9+/-4.7) and those without IOA (9.2+/-4.0 vs. 6.7+/-3.5). SOFApreinf represented 85.7% of the value of SOFAmax in patients with IAI. SOFApreinf increased significantly with the occurrence of sepsis, severe sepsis, or septic shock during ICU stay. Severe sepsis and septic shock during ICU stay as well as SOFApreinf were part of the factors associated with hospital mortality. CONCLUSIONS: IAI is significantly associated with hospital mortality; however, its contribution to OD/F is minor. Moreover, severity of IAI seems to be related to previous health status.
Researchers ; Professionals
http://hdl.handle.net/2268/72652

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