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| Reference : Le sepsis, réponse adaptée ou non à l’infection? |
| Scientific journals : Article | |||
| Human health sciences : Anesthesia & intensive care | |||
| http://hdl.handle.net/2268/72649 | |||
| Le sepsis, réponse adaptée ou non à l’infection? | |
| French | |
| [en] Sepsis, adaptive or maladaptive response to infection? | |
Damas, Pierre  [Université de Liège - ULg > > Soins intensifs >] | |
| 2009 | |
| Réanimation | |
| 18 | |
| 4 | |
| 277-281 | |
| International | |
| [en] Sepsis ; Inflammation | |
| [fr] Choc septique ; Facteurs de virulence | |
| [en] Sepsis, severe sepsis and septic shock were thought to be provoked by an overwhelming
inflammation in response to an infectious process. This was documented in several animal studies. However, in human sepsis, excess of inflammation is hard to be observed. Compartimentalization of the host response rather favors a systemic anti-inflammatory climate. Clinical situations are complex: on one hand, virulence factors of microorganisms can directly harm the host tissues, divert the defence mechanisms or distract the control mechanisms of the host, preventing the normal interaction of endogenous mediators. On the other hand, septic shock mostly occurs in patients experiencing previous organic or functional vital failures before the development of infection. The vulnerability of the patient appears therefore to be a key point in the severity of the disease. Enhancing the host defence mechanisms rather than inhibiting the inflammatory reaction may become a preferential option. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/72649 |
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