ORBi: Bozukova Dimitriya - Plasma surface fluorination of hydrogel materials-coating stability and in vitro biocompatibility testing

Reference : Plasma surface fluorination of hydrogel materials-coating stability and in vitro biocomp...


	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Materials science & engineering Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/72482

Title :	Plasma surface fluorination of hydrogel materials-coating stability and in vitro biocompatibility testing
Language :	English
Author, co-author :	Bozukova, Dimitriya [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Pagnoulle, Christophe [Physiol SA, Belgium > > > >]
	Gillet, Marie-Claire [University of Liège (ULg) > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology > >]
	Klee, Doris [RWTH Aachen, Germany > > Lehrstuhl für Textilchemie und Makromolekulare Chemie > >]
	Dupont-Gillain, Christine [Université Catholique de Louvain (UCL) > > Unité de Chimie des Interfaces > >]
	Duwez, Anne-Sophie [University of Liège (ULg) > Department of Chemistry > Nanochemistry and Molecular Systems > >]
	Gilbert, Yann [University of Liège (ULg) > Department of Chemistry > Nanochemistry and Molecular Systems > >]
	Jérôme, Robert [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	9-Mar-2010
Journal title :	Soft Materials
Publisher :	Taylor & Francis Ltd
Volume :	8
Issue/season :	2
Pages :	164-182
Audience :	International
ISSN :	1539-445X
Keywords :	[en] biomaterial ; intraocular lens ; coating ; implant
Abstract :	[en] Plasma enhanced chemical vapor deposition has been tested for the formation of hydrophobic perfluorinated coating on the surface of hydrophilic poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) [poly(HEMA-co-MMA)] substrates, used for the fabrication of intraocular lenses (IOLs). The properties of the dry and hydrated surface modified by two plasma techniques, Radio-frequency (RF) and Microwave (MW), were investigated in parallel by contact angle measurements in the dry and hydrated state, X-ray photoelectron spectroscopy, and atomic force microscopy. The coating stability and hydrophobicity were challenged by swelling and sterilizing the samples in water. Investigation of the optical performances of the modified samples was performed by ultraviolet spectroscopy and diopter measurements. Since materials with biomedical application are considered, the performances of their surface in contact with lens epithelial cells were tested at in vitro conditions, and repulsion was not found to be enhanced upon modification. Generally, the results showed poor stability of the coating and bring in question its covalent grafting to the surface.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	The Walloon Region of Belgium in the frame of the “First Europe (SURFOLIO) program ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/72482
DOI :	10.1080/15394451003756365
Other URL :	http://www.informaworld.com/smpp/ftinterface~content=a923177593~fulltext=713240930~frm=content

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Restricted access	Bozukova D 2010 Soft Mat 8, 164.pdf		Publisher postprint	2.93 MB	Request copy

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