Article (Scientific journals)
Les transplantations de cellules de Schwann syngéniques dans les lésions médullaires: résultats, limitations et perspectives
Martin, Didier
1994In Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 149 (5-7), p. 279-89, discussion 289-91
 

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Abstract :
[en] After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at least in part, to the existence in the periphery of Schwann cells and of growth promoting proteins they synthetize. One strategy to promote regrowth of central axons can be therefore, to modify (i.e. "peripheralize") the microenvironment by transplanting biologically active Schwann cells into the lesion site. In a rat model of traumatic paraplegia by inflation of a subdural microballoon, we performed syngeneic transplants of Schwann cells. These cells are cultured from adult dorsal root ganglia and can be kept in vitro for several months. They are transplanted in the injured spinal cord. The grafted Schwann cells are well integrated in the host tissue without detectable inflammatory reaction. Cystic cavitation and astrogliosis are reduced in grafted animals as compared to injured, non-grafted animals. The transplant is invaded by abundant, mainly unmyelinated axons which are immunoreactive for substance P, VIP or CGRP, i.e. transmitters known to be present in DRG afferents. Supraspinal afferents containing 5HT, TH or CCK accumulate at the rostral margin of the graft. Experimental procedures trying to stimulate the invasion of the graft by descending fibers, i.e. by inducing a chemoattraction are therefore of crucial importance for functional recovery.
Disciplines :
Surgery
Author, co-author :
Martin, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie
Language :
French
Title :
Les transplantations de cellules de Schwann syngéniques dans les lésions médullaires: résultats, limitations et perspectives
Alternative titles :
[en] The Transplantation of Syngeneic Schwann Cells in Medullary Lesions: Results, Limitations and Perspectives
Publication date :
1994
Journal title :
Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique
ISSN :
0377-8231
Publisher :
Academie Royale de Médecine de Belgique, Bruxelles, Belgium
Volume :
149
Issue :
5-7
Pages :
279-89, discussion 289-91
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