Reference : EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Pr...
Scientific journals : Article
Human health sciences : Rheumatology
http://hdl.handle.net/2268/72431
EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Prevalence of inflammation in osteoarthritis
English
D'Agostino, M. A. [> > > >]
Conaghan, P. [> > > >]
Le Bars, M. [> > > >]
Baron, G. [> > > >]
Grassi, W. [> > > >]
Martin-Mola, E. [> > > >]
Wakefield, R. [> > > >]
Brasseur, J. L. [> > > >]
So, A. [> > > >]
Backhaus, M. [> > > >]
Malaise, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Rhumatologie >]
Burmester, G. [> > > >]
Schmidely, N. [> > > >]
Ravaud, P. [> > > >]
Dougados, M. [> > > >]
Emery, P. [> > > >]
Dec-2005
Annals of the Rheumatic Diseases
BMJ Group
64
12
1703-1709
Yes (verified by ORBi)
International
0003-4967
1468-2060
London
United Kingdom
[en] Exudates and Transudates ; Osteoarthritis, Knee ; Pain Measurement
[en] Objectives: To assess the prevalence of inflammation in subjects with chronic painful knee osteoarthritis (OA), as determined by the presence of synovitis or joint effusion at ultrasonography (US); and to evaluate the correlation between synovitis, effusion, and clinical parameters. Methods: A cross sectional, multicentre, European study was conducted under the umbrella of EULAR-ESCISIT. Subjects had primary chronic knee OA (ACR criteria) with pain during physical activity >= 30 mm for at least 48 hours. Clinical parameters were collected by a rheumatologist and an US examination of the painful knee was performed by a radiologist or rheumatologist within 72 hours of the clinical examination. Ultrasonographic synovitis was defined as synovial thickness >= 4 mm and diffuse or nodular appearance, and a joint effusion was defined as effusion depth >= 4 mm. Results: 600 patients with painful knee OA were analysed. At US 16 (2.7%) had synovitis alone, 85 (14.2%) had both synovitis and effusion, 177 (29.5%) had joint effusion alone, and 322 (53.7%) had no inflammation according to the definitions employed. Multivariate analysis showed that inflammation seen by US correlated statistically with advanced radiographic disease (Kellgren-Lawrence grade >= 3; odds ratio (OR) = 2.20 and 1.91 for synovitis and joint effusion, respectively), and with clinical signs and symptoms suggestive of an inflammatory "flare'', such as joint effusion on clinical examination (OR = 1.97 and 2.70 for synovitis and joint effusion, respectively) or sudden aggravation of knee pain (OR = 1.77 for joint effusion). Conclusion: US can detect synovial inflammation and effusion in painful knee OA, which correlate significantly with knee synovitis, effusion, and clinical parameters suggestive of an inflammatory "flare''.
Researchers ; Professionals
http://hdl.handle.net/2268/72431

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