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| Reference : Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury |
| Scientific journals : Article | |||
| Human health sciences : Surgery Social & behavioral sciences, psychology : Neurosciences & behavior Human health sciences : Neurology | |||
| http://hdl.handle.net/2268/7227 | |||
| Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury | |
| English | |
| Schmitt, Andreas B. [> > > >] | |
| Breuer, Sebastien [> > > >] | |
| Polat, Leyla [> > > >] | |
| Pech, Katrin [> > > >] | |
| Kakulas, Byran [> > > >] | |
| Love, Seth [> > > >] | |
Martin, Didier  [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie] | |
| Schoenen, Jean [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie] | |
| Noth, Johannes [> > > >] | |
| Brook, Gary A. [> > > >] | |
| Oct-2003 | |
| Annals of Neurology | |
| Wiley Liss, Inc. | |
| 54 | |
| 4 | |
| 534-539 | |
| Yes (verified by ORBi) | |
| International | |
| 0364-5134 | |
| New York | |
| [en] Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time. | |
| http://hdl.handle.net/2268/7227 |
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