Reference : Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
Human health sciences : Surgery
http://hdl.handle.net/2268/7227
Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury
English
Schmitt, Andreas B. [> > > >]
Breuer, Sebastien [> > > >]
Polat, Leyla [> > > >]
Pech, Katrin [> > > >]
Kakulas, Byran [> > > >]
Love, Seth [> > > >]
Martin, Didier mailto [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Noth, Johannes [> > > >]
Brook, Gary A. [> > > >]
Oct-2003
Annals of Neurology
Wiley Liss, Inc.
54
4
534-539
Yes (verified by ORBi)
International
0364-5134
New York
[en] Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.
http://hdl.handle.net/2268/7227

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