[en] This paper will be mainly illustrated with references to selected antiplasmodial compounds:- indole alkaloid analogues of emetine isolated from Strychnos usambarensis and Pogonopus tubulosus-other bisindole alkaloids isolated from Loganiacea and Apocynaceae -indoloquinolines (cryptolepine and analogues) -indolo quinazoline-6,12-diones and derivatives from Strobilanthes and other sources -aminopolycyclic beta-carbolines ( manzamines) !solated from Indo-Pacific sponges. The paper will be finally also focused on the design of chemosensitizers that are capable of reversing in vitro chloroquine resistance( case of some mono-indole alkaloids).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Philippe, Geneviève ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
French
Title :
Potentialités antipaludiques des alcaloïdes indoliques
Alternative titles :
[en] Potential antimalarial activity of indole alkaloids
Publication date :
2007
Journal title :
Actualités de Chimie Thérapeutique
Publisher :
Société de Chimie Thérapeutique, Paris, France
Volume :
33
Pages :
1-32
Commentary :
Paper of a lecture presented by one of us (L.A.) at the 42nd International meeting on Medicinal Chemistry that has been hold at Marseilles ( France) in July 2006.
