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| Reference : Poly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D,L-lactide) copolym... |
| Scientific journals : Article | |||
| Life sciences : Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering Human health sciences : Surgery | |||
| http://hdl.handle.net/2268/7222 | |||
| Poly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D,L-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration | |
| English | |
| Maquet, Véronique [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
Martin, Didier  [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie] | |
| Scholtes, Félix [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie >] | |
| Franzen, Rachelle [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >] | |
| Schoenen, Jean [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie] | |
| Moonen, Gustave [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine] | |
| Jérôme, Robert [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| May-2001 | |
| Biomaterials | |
| Elsevier | |
| 22 | |
| 10 | |
| 1137-1146 | |
| International | |
| 0142-9612 | |
| [en] Poly(D,L-lactide) porous supports ; Poly(ethylene oxide)-block-poly(D,L-lactide) copolymer ; Acidic fibroblast growth factor ; In vitro degradation ; Central nervous system ; Spinal cord ; Regeneration ; biomaterial ; scaffold | |
| [en] The first goal of this study was to examine the influence that poly(ethylene oxide)-block-poly(D,L-lactide) (PELA) copolymer can have on the wettability, the in vitro controlled delivery capability, and the degradation of poly(D,L-lactide) (PDLLA) foams. These foams were prepared by freeze-drying and contain micropores (10 μm) in addition of macropores (100 μm) organized longitudinally. Weight loss, water absorption, changes in molecular weight, polymolecularity (Mw/Mn) and glass transition temperature ( Tg) of PDLLA foams mixed with various amounts of PELA were followed with time. It was found that 10 wt% of PELA increased the wettability and the degradation rate of the polymer foams. The release of sulforhodamine (SR) was compared for PDLLA and PDLLA-PELA foams in relation with the foam porosity. An initial burst release was observed only in the case of the 90:10 PDLLA/PELA foam. The ability of the foam of this composition to be integrated and to promote tissue repair and axonal regeneration in the transected rat spinal cord was investigated. After implantation of ca. 20 polymer rods assembled with fibrin-glue, the polymer construct was able to bridge the cord stumps by forming a permissive support for cellular migration, angiogenesis and axonal regrowth. | |
| Center for Education and Research on Macromolecules (CERM) | |
| Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy | |
| Researchers | |
| http://hdl.handle.net/2268/7222 | |
| 10.1016/S0142-9612(00)00357-4 | |
| http://www.elsevier.com/wps/find/journaldescription.cws_home/30392/description#description | |
| The authors acknowledge Biomaterials (Elsevier) for allowing them to archive this paper. |
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