Reference : Poly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D,L-lactide) copo...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
Human health sciences : Surgery
http://hdl.handle.net/2268/7222
Poly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D,L-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration
English
Maquet, Véronique [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Martin, Didier mailto [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie]
Scholtes, Félix mailto [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie >]
Franzen, Rachelle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
May-2001
Biomaterials
Elsevier
22
10
1137-1146
Yes (verified by ORBi)
International
0142-9612
[en] Poly(D,L-lactide) porous supports ; Poly(ethylene oxide)-block-poly(D,L-lactide) copolymer ; Acidic fibroblast growth factor ; In vitro degradation ; Central nervous system ; Spinal cord ; Regeneration ; biomaterial ; scaffold
[en] The first goal of this study was to examine the influence that poly(ethylene oxide)-block-poly(D,L-lactide) (PELA) copolymer can have on the wettability, the in vitro controlled delivery capability, and the degradation of poly(D,L-lactide) (PDLLA) foams. These foams were prepared by freeze-drying and contain micropores (10 μm) in addition of macropores (100 μm) organized longitudinally. Weight loss, water absorption, changes in molecular weight, polymolecularity (Mw/Mn) and glass transition temperature ( Tg) of PDLLA foams mixed with various amounts of PELA were followed with time. It was found that 10 wt% of PELA increased the wettability and the degradation rate of the polymer foams. The release of sulforhodamine (SR) was compared for PDLLA and PDLLA-PELA foams in relation with the foam porosity. An initial burst release was observed only in the case of the 90:10 PDLLA/PELA foam. The ability of the foam of this composition to be integrated and to promote tissue repair and axonal regeneration in the transected rat spinal cord was investigated. After implantation of ca. 20 polymer rods assembled with fibrin-glue, the polymer construct was able to bridge the cord stumps by forming a permissive support for cellular migration, angiogenesis and axonal regrowth.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/7222
10.1016/S0142-9612(00)00357-4
http://www.elsevier.com/wps/find/journaldescription.cws_home/30392/description#description
The authors acknowledge Biomaterials (Elsevier) for allowing them to archive this paper.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Maquet_V_2001_Biomaterials_22_10_1137.pdfNo commentaryAuthor postprint3.32 MBView/Open
Restricted access
Biomaterials 22 (2001) 1137-1146 - Maquet - polylactide.pdfNo commentaryPublisher postprint905.81 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.