Reference : Nt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
Scientific journals : Article
Human health sciences : Surgery
http://hdl.handle.net/2268/7218
Nt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
English
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Lefebvre, P. P. [> > > >]
Martin, Didier mailto [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie]
Staecker, H. [> > > >]
Van de Water, T. R. [> > > >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
4-Nov-1996
Neuroreport
7
15-17
2495-9
Yes (verified by ORBi)
International
0959-4965
[en] CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.
http://hdl.handle.net/2268/7218

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