ORBi: Delree P. - Plasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro

Reference : Plasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/2268/7207

Title :	Plasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro
Language :	English
Author, co-author :	Delree, P. [> > > >]
	Ribbens, Clio [Centre Hospitalier Universitaire de Liège - CHU > > Rhumatologie >]
	Martin, Didier [Université de Liège - ULg > Département des sciences cliniques > Neurochirurgie]
	Rogister, Bernard [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
	Lefebvre, P. P. [> > > >]
	Rigo, Jean-Michel [ > > ]
	Leprince, Pierre [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
	Schoenen, Jean [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
	Moonen, Gustave [Université de Liège - ULg > > Neurologie Sart Tilman >]
Publication date :	1993
Journal title :	Brain Research Bulletin
Volume :	30
Issue/season :	3-4
Pages :	231-7
Audience :	International
ISSN :	0361-9230
Abstract :	[en] We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo are also mentioned. Cultured developing and adult DRG neurons can be switched from an apolar to a multipolar phenotype by fetal calf serum or fibronectin. The effect is concentration dependent and occurs through an early modification of cell-substratum interaction. Adult DRG neurons synthesize and release within hours after injury TGF beta-1, which is a mitogen and a differentiation factor for Schwann cells. Finally, adult DRG neurons express in vitro neurotransmitters that are not expressed in vivo. This neurotransmitter plasticity can be modulated in vitro by some growth factors and in vivo by distal or proximal axotomy.
Permalink :	http://hdl.handle.net/2268/7207

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