Reference : Bone Sialoprotein Mrna and Protein Expression in Human Multiple Myeloma Cell Lines and P...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/7167
Bone Sialoprotein Mrna and Protein Expression in Human Multiple Myeloma Cell Lines and Patients
English
Bellahcene, Akeila mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Labo de recherche sur les métastases >]
Van Riet, I. [> > > >]
de Greef, C. [> > > >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
Young, M. F. [> > > >]
Van Camp, B. [> > > >]
Castronovo, Vincenzo mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]
Dec-2000
British Journal of Haematology
111
4
1118-21
Yes (verified by ORBi)
International
0007-1048
[en] Bone sialoprotein (BSP) is a glycoprotein essentially found in mineralizing connective tissues. We have recently demonstrated that BSP is ectopically expressed by carcinomas that metastasize to bone with high frequency. Multiple myeloma (MM) is characterized by the localization of tumour plasma cells in the bone marrow. In this study, BSP expression was evaluated in human myeloma cell lines and in bone marrow aspirates and one ascites fluid from MM patients. BSP was detectable in conditioned media of MM cell lines. Using FACS analysis and in situ hybridization, we demonstrated that tumour cells from all MM patients and cell lines analysed express BSP at both the protein and the mRNA level.
http://hdl.handle.net/2268/7167

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