ORBi: Rozet Eric - Validation of a fast gas chromatographic method for the study of semiochemical slow release formulations

Reference : Validation of a fast gas chromatographic method for the study of semiochemical slow rele...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Entomology & pest control Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/71663

Title :	Validation of a fast gas chromatographic method for the study of semiochemical slow release formulations
Language :	English
Author, co-author :	Rozet, Eric [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
	Heuskin, Stéphanie [Université de Liège - ULg > Chimie et bio-industries > Chimie analytique >]
	Lorge, Stéphanie [> >]
	Farmakidis, Julien [Université de Liège - ULg > Sciences agronomiques > Entomologie fonctionnelle et évolutive >]
	Hubert, Philippe [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
	Verheggen, François [Université de Liège - ULg > Sciences agronomiques > Entomologie fonctionnelle et évolutive >]
	Haubruge, Eric [Université de Liège - ULg > Services administratifs généraux > Vice-Recteur de Gembloux Agro Bio Tech - Entomologie fonctionnelle et évolutive >]
	Wathelet, Jean-Paul [Université de Liège - ULg > Chimie et bio-industries > Chimie générale et organique >]
	Lognay, Georges [Université de Liège - ULg > Chimie et bio-industries > Chimie analytique >]
Publication date :	2010
Journal title :	Journal of Pharmaceutical & Biomedical Analysis
Publisher :	Elsevier Science
Volume :	53
Pages :	962-972
Audience :	International
ISSN :	0731-7085
City :	Oxford
Country :	United Kingdom
Keywords :	[en] validation ; accuracy profile ; sesquiterpenes ; alginate beads ; semiochemicals
Abstract :	[en] The validation of a fast GC-FID analytical method for the quantitative determination of semiochemical sesquiterpenes (E-β-farnesene and β-caryophyllene) to be used in an integrated pest management approach is described. Accuracy profiles using total error as decision criteria for validation were used to verify the overall accuracy of the method results within a well defined range of concentrations and to determine the lowest limit of quantification for each analyte. Furthermore it allowed to select a very simple and reliable regression model for calibration curve for the quantification of both analytes as well as to provide measurement uncertainty without any additional experiments. Finally, this validated method was used for the quantification of semiochemicals in slow release formulations. The goal was to verify the protection efficiency of alginate gel beads formulations against oxidation and degradation of sesquiterpenes. The results showed that the alginate beads are adequate slow release devices which protect the bio-active molecules during at least twenty days.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/71663
DOI :	10.1016/j.jpba.2010.07.014

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