Reference : Les anomalies morphologiques et metaboliques liees aux traitements antiretroviraux
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/71555
Les anomalies morphologiques et metaboliques liees aux traitements antiretroviraux
French
[en] Morphological and Metabolic Abnormalities Related to Antiretroviral Therapy
Debruyn, X. [> > > >]
Nkoghe, D. [> > > >]
Leonard, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
Demonty, Jean [Université de Liège - ULg > > Maladies infectieuses et médecine interne générale >]
Jan-2002
Revue Médicale de Liège
57
1
23-8
Yes (verified by ORBi)
National
0370-629X
[en] The long term use of antiretroviral therapy is associated with metabolic and morphological abnormalities named lipodystrophy. The understanding of its epidemiology is in progress. NRTIs and Pls are involved in the origin of these abnormalities. So, NRTIs inhibit mitochondrial gamma polymerase and induce body fat distribution disorders. PIs interfere with lipid metabolism, leading to hyperlipidaemia and insulin resistance symptomatology. The diagnosis is made by clinical (far wasting or accumulation, or mixed syndrome) and biological signs (hyperlipidaemia, hyperglycaemia, hyperlactacidaemia). Radiological exams can quantify morphological abnormalities. The management consists in drug substitution, diet and exercise, and corrective drugs. Plastic surgery can be useful.
http://hdl.handle.net/2268/71555

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Les anomalies morphologiques et metaboliques liees aux traitements antiretroviraux - 2002.pdfPublisher postprint448.98 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.