Article (Scientific journals)
Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults
Moutschen, Michel; Leonard, Philippe; Sokal, E. M. et al.
2007In Vaccine, 25 (24), p. 4697-4705
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Keywords :
Epstein-Barr virus (EBV); vaccine; gp350
Abstract :
[en] Two double-blind randomised controlled studies (phase I and I/II) were performed to assess for the first time the safety and immunogenicity of a recombinant subunit gp350 Epstein-Barr virus (EBV) vaccine in 148 healthy adult volunteers. All candidate vaccine formulations had a good safety profile and were well tolerated, with the incidence of solicited and unsolicited symptoms within a clinically acceptable range. One serious adverse event was reported in the phase I trial which was considered to be of suspected relationship to vaccination. The gp350 vaccine formulations were immunogenic and induced gp350-specific antibody responses (including neutralising antibodies). (c) 2007 Elsevier Ltd. All rights reserved.
Disciplines :
Veterinary medicine & animal health
Laboratory medicine & medical technology
Immunology & infectious disease
Author, co-author :
Moutschen, Michel  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Leonard, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Sokal, E. M.
Smets, F.
Haumont, M.
Mazzu, P.
Bollen, A.
Denamur, F.
Peeters, P.
Dubin, G.
Denis, M.
Language :
English
Title :
Phase I/II studies to evaluate safety and immunogenicity of a recombinant gp350 Epstein-Barr virus vaccine in healthy adults
Publication date :
11 June 2007
Journal title :
Vaccine
ISSN :
0264-410X
eISSN :
1873-2518
Publisher :
Elsevier Sci Ltd, Oxford, United Kingdom
Volume :
25
Issue :
24
Pages :
4697-4705
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 September 2010

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