Reference : HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apo...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/71402
HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha plus TSA
English
Vandergeeten, Claire [Université de Liège - ULg > > Immunopathologie - Transplantation >]
Quivy, Vincent [Université Libre de Bruxelles - ULB > Institute for Molecular Medicine & Biology > Laboratory of Molecular Virology > >]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
Van Lint, Carine [Université Libre de Bruxelles - ULB > Institute for Molecular Medicine & Biology > Laboratory of Molecular Virology > >]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > Virologie - Immunologie >]
Legrand-Poels, S. [> > > >]
2007
Biochemical Pharmacology
Pergamon-Elsevier Science Ltd
73
11
1738-1748
Yes (verified by ORBi)
International
0006-2952
Oxford
United Kingdom
[en] HIV-1 protease inhibitor ; NF-kappa B ; apoptosis
[en] HIV-1 latency represents a major hurdle to the complete eradication of the virus from patients under highly active anti-retroviral therapy (HAART) regimens. One solution to this problem would be to eliminate the latently infected cellular reservoirs by forcing gene expression in presence of HAART to prevent spreading of the infection by the newly synthesized viruses. Many studies have reported that a combination of a histone deacetylase inhibitor (HDACi) (i.e. TSA, NaBut, Valproic acid,...) with a pro-inflammatory cytokine (i.e. TNF alpha, IL-1,...) reactivates in a synergistic manner HIV-1 transcription in latently infected cells. The aim of the present study was to determine whether HIV-1 protease inhibitors (PIs) used in HAART (such as Saquinavir, Indinavir, Nelfinavir, Lopinavir, Ritonavir and Amprenavir) could interfere with the potential purge of the cellular reservoirs induced by a combined treatment involving TSA and TNF alpha. We showed, in two HIV-1 latently infected cell lines (ACH-2 and U1) that all PIs efficiently inhibited release of mature viral particles but did neither affect cell apoptosis nor NF-kappa B induction and HIV-1 transcription activation following combined treatment with TNF alpha + TSA. This study is encouraging in the fight against HIV-1 and shows that PIs should be compatible with an inductive adjuvent therapy for latent reservoir reduction/elimination in association with efficient HAART regimens. (c) 2007 Elsevier Inc. All rights reserved.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/71402
also: http://hdl.handle.net/2268/100328
10.1016/j.bcp.2007.02.011

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