Reference : Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Appr...
Scientific journals : Article
Engineering, computing & technology : Mechanical engineering
Human health sciences : Rheumatology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/71390
Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach
English
Geris, Liesbet mailto [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
Reed, Anita A.C. [ > > ]
Vander Sloten, Jos [ > > ]
Simpson, A. Hamish R.W. [ > > ]
Van Oosterwyck, Hans [ > > ]
Sep-2010
PLoS Computational Biology
Public Library of Science
6
9
1000915
Yes (verified by ORBi)
International
1553-734X
1553-7358
San Francisco
CA
[en] Recently developed atrophic non-union models are a good representation of the clinical situation in which many nonunions develop. Based on previous experimental studies with these atrophic non-union models, it was hypothesized that in order to obtain successful fracture healing, blood vessels, growth factors, and (proliferative) precursor cells all need to be present in the callus at the same time. This study uses a combined in vivo-in silico approach to investigate these different aspects (vasculature, growth factors, cell proliferation). The mathematical model, initially developed for the study of normal fracture healing, is able to capture essential aspects of the in vivo atrophic non-union model despite a number of deviations that are mainly due to simplifications in the in silico model. The mathematical model is subsequently used to test possible
treatment strategies for atrophic non-unions (i.e. cell transplant at post-osteotomy, week 3). Preliminary in vivo experiments corroborate the numerical predictions. Finally, the mathematical model is applied to explain experimental observations and
identify potentially crucial steps in the treatments and can thereby be used to optimize experimental and clinical studies in this area. This study demonstrates the potential of the combined in silico-in vivo approach and its clinical implications for the early treatment of patients with problematic fractures.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/71390
10.1371/journal.pcbi.1000915
http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000915
This article was covered by Reflexions: http://reflexions.ulg.ac.be/cms/c_28892/le-genie-biomedical-tombe-sur-un-os.

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