Reference : Interfaces between dendritic cells, other immune cells, and nerve fibres in mouse Peyer'...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/7136
Interfaces between dendritic cells, other immune cells, and nerve fibres in mouse Peyer's patches: Potential sites for neuroinvasion in prion diseases
English
Defaweux, Valérie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Dorban, Gauthier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Demonceau, Christine mailto [Université de Liège - ULg > Département de personne et société > Psychologie du travail et des entreprises >]
Piret, Julie [Centre Hospitalier Universitaire de Liège - CHU > > HOSPITALISATION - CHIR. APP. LOCOMOT. (SN +2A) >]
Jolois, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Thellin, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Thielen, Caroline mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
1-Jan-2005
Microscopy Research and Technique
Wiley Liss, Inc.
66
1
1-9
Yes (verified by ORBi)
International
1059-910X
Hoboken
[en] mouse ; Peyer's patches ; dendritic cells ; follicular dendritic cells ; nerve fibres ; prion
[en] In this study, we examined where immune cells and nerve fibres are located in mouse Peyer's patches, with a view to identifying potential sites for neuroinvasion by prions. Special attention was paid to dendritic cells, viewed as candidate transporters of infectious prion. Double immunofluorescence labellings with anti-CD11c antibody and marker for other immune cells (B cells, T cells, follicular dendritic cells) were carried out and analysed by confocal microscopy on Peyer's patch cryosections. To reveal the extensive ganglionated networks of the myenteric and submucosal plexi and the sparse meshworks of nerve strands, we used antibodies directed against different neurofilament subunits or against glial fibrillary acidic protein. In the suprafollicular dome, dendritic cells connect, via their cytoplasmic extensions, enterocytes with M cells of the follicle-associated epithelium. They are also close to B and T cells. Nerve fibres are detected in the suprafollicular dome, notably in contact with dendritic cells. Similar connections between dendritic cells, T cells, and nerve fibres are seen in the interfollicular region. Germinal centres are not innervated; inside them dendritic cells establish contacts with follicular dendritic cells and with B cells. After immunolabelling of normal prion protein, dendritic cells of the suprafollicular dome are intensely positive labelled. (c) 2005 Wiley-Liss, Inc.
http://hdl.handle.net/2268/7136

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Micros.Res.Tech. 2005.pdfAuthor postprint563.73 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.