[en] Follicular dendritic cells (FDCs) are a unique population of accessory cells located in the light zone of the germinal centres of lymphoid follicles. Their involvement in the generation of Immoral immune responses implies a potential role for these cells in many disorders. Indeed, in prion diseases, FDCs seem to be the major sites of extraneuronal cellular prion protein expression and the principal sites of the infectious agent accumulation in lymphoid organs. The identification of FDC is useful for the analysis of their distribution in reactive lymphoid tissue as well as in pathological conditions. The production and characterisation of a new mouse monoclonal antibody directed against bovine follicular dendritic cells (FDC-B1) is reported. The antigen detected by FDC-B1 is expressed exclusively on the surface of FDCs in ruminant lymphoid organs. The antigen has an approximate molecular weight of 28 kDa. (C) 2003 Elsevier B.V. All rights reserved.
Disciplines :
Veterinary medicine & animal health Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Defaweux, Valérie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Mélot, France ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)
Jolois, Olivier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Collard, A.
Robert, B.
Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Antoine, Nadine ; Université de Liège - ULiège > Département de morphologie et pathologie > Histologie
Language :
English
Title :
FDC-B1: a new monoclonal antibody directed against bovine follicular dendritic cells
Publication date :
January 2004
Journal title :
Veterinary Immunology and Immunopathology
ISSN :
0165-2427
eISSN :
1873-2534
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
97
Issue :
1-2
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
France Mélot et Valérie Defaweux sont toutes les deux co-auteurs de ce papiers
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