Reference : The repressing function of the oncoprotein BCL-3 requires CtBP while its polyubiquitinat...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/71243
The repressing function of the oncoprotein BCL-3 requires CtBP while its polyubiquitination and degradation involve the E3 ligase TBLR1
English
Keutgens, Aurore mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Shostak, Kateryna mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Close, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Zhang-Shao, Xin [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Hennuy, Benoît mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme transcriptomique >]
Aussems, Marie [ > > ]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > > Chimie médicale >]
Viatour, Patrick [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Gothot, André mailto [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]
Fillet, Marianne mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Aug-2010
Molecular & Cellular Biology
American Society for Microbiology (ASM)
30
4006-4021
Yes (verified by ORBi)
International
0270-7306
1098-5549
Washington
DC
[en] NF-kappa B ; BCL-3 ; polyubiquitination
[en] The nuclear and oncogenic BCL-3 protein activates or represses gene transcription when bound to NF-kB proteins p50 and p52, yet the molecules that specifically interact with BCL-3 and drive BCL-3-mediated effects on gene expression remain largely uncharacterized. Moreover, GSK3-mediated phosphorylation of BCL-3 triggers its degradation through the proteasome, but the proteins involved in this degradative pathway are poorly characterized. Biochemical purification of interacting partners of BCL-3 led to the identification of CtBP as a molecule required for the ability of BCL-3 to repress gene transcription. CtBP is also required for
the oncogenic potential of BCL-3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes. We also defined the E3 ligase TBLR1 as a protein involved in BCL-3 degradation through a GSK3-independent pathway. Thus, our data demonstrate that the LSD1/CtBP complex is required for the repressing abilities of an oncogenic IkB protein, and they establish a functional link between the E3 ligase TBLR1 and NF-kB.
Giga-Signal Transduction
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS, TELEVIE, Fédération Belge contre le Cancer
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/71243

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