Reference : Oral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/7122
Oral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells
English
Dorban, Gauthier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Defaweux, Valérie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Levavasseur, Etienne mailto [Institut National de la Santé et de la Recherche Médicale - INSERM > > > > > >]
Thellin, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Flandroy, Sylvain [> > > >]
Piret, Joëlle mailto [Université de Liège - ULg > Département de morphologie et pathologie > Département de morphologie et pathologie >]
Falisse-Poirier, Nandini [> > > >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
Sep-2007
Histochemistry & Cell Biology
Springer
128
3
243-251
Yes (verified by ORBi)
International
0948-6143
New York
[en] prion ; dendritic cell ; Peyer's patches ; mucosal immunity
[en] In transmitted prion diseases the immune system supports the replication and the propagation of the pathogenic agent (PrPSc). DCs, which are mobile cells present in large numbers within lymph organs, are suspected to carry prions through the lymphoid system and to transfer them towards the peripheral nervous system. In this study, C57Bl/6 mice were orally inoculated with PrPSc (scrapie strain 139A) and sacrificed at the preclinical stages of the disease. Immunolabelled cryosections of Peyer's patches were analysed by confocal microscopy. Membrane prion protein expression was studied by flow cytometry. In Peyer's patches (PP), dissected at day one and day 105 after oral exposure to scrapie, we observed an increased population of DCs localised in the follicular-associated epithelium. On day 105, PrPSc was found in the follicles inside the PP of prion-infected mice. A subset of Peyer's patches DCs, which did not express cellular prion protein on their surface in non-infected mice conditions, was prion-positive in scrapie conditions. Within Peyer's patches oral scrapie exposure thus induced modifications of the homeostasis of DCs at the preclinical stages of the disease. These results give new arguments in favour of the implication of DCs in prion diseases.
http://hdl.handle.net/2268/7122

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