Reference : Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrap...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/7117
Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure
English
Dorban, Gauthier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Defaweux, Valérie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Demonceau, Christine mailto [Université de Liège - ULg > Département d'Histologie > Histologie > >]
Flandroy, Sylvain [> > > >]
Van Lerberghe, Pierre-Bernard [> > > >]
Falisse-Poirier, Nandini [> > > >]
Piret, Joëlle mailto [Université de Liège - ULg > Département de morphologie et pathologie > Département de morphologie et pathologie > >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
Dec-2007
Virchows Archiv
Springer
451
6
1057-1065
Yes (verified by ORBi)
International
0945-6317
New York
[en] prion ; dendritic cells ; innervation
[en] In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuro-invasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process.
http://hdl.handle.net/2268/7117

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