Reference : Prevention of bacterial biofilms by covalent immobilization of peptides onto plasma poly...
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/71037
Prevention of bacterial biofilms by covalent immobilization of peptides onto plasma polymer functionalized substrates
English
Vreuls, Christelle mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Zocchi, Germaine mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Thierry, Benjamin [Ian Wark Research Institute, University of South Australia > > > > > >]
Garitte, Geoffrey mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Griesser, Stefani S [Ian Wark Research Institute, University of South Australia > > > > > >]
Archambeau, Catherine [ArcelorMittal Research Liège > New coating technologies > > >]
Van de Weerdt, Cécile mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Griesser, Hans [Ian Wark Research Institute, University of South Australia > > > > > >]
2010
Journal of Materials Chemistry
Royal Society of Chemistry
20
8092 - 8098
Yes (verified by ORBi)
International
0959-9428
1364-5501
Cambridge
United Kingdom
[en] In this study, robust antibacterial coatings were created on stainless steel through the covalent grafting of antibacterial peptides onto an organic-polymeric interlayer deposited by RF-glow discharge plasma. X-Ray photoelectron spectroscopy was used to characterize and optimize the two steps of the coating process. The biocidal activity of these surfaces was demonstrated against both Gram+ and Gram- bacteria using ISO tests. 3 to 6 log10 reductions of both Gram+ and Gram- bacterial strains were obtained compared to uncoated stainless steel and depending on the particular antibacterial peptide immobilized. Importantly the antibacterial surfaces were resistant to several cleaning conditions. The latter is significant as the stability of such antibacterial surfaces in close to real life conditions is a major concern and leaching, de-lamination, rearrangement and ageing of the coating can lead to insufficient long term biofilm resistance of the surface.
Giga-Systems Biology and Chemical Biology ; Ian Wark Research Institute, University of South Australia ; ArcelorMittal Research Liège
Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Biocoat
http://hdl.handle.net/2268/71037
10.1039/c0jm01419b

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