ORBi: Amor Nadya - Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration around Endosseous Oral Implants: In Silico Modeling

Reference : Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration around End...


	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Life sciences : Microbiology Engineering, computing & technology : Mechanical engineering Engineering, computing & technology : Computer science Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/70870

Title :	Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration around Endosseous Oral Implants: In Silico Modeling
Language :	English
Author, co-author :	Amor, Nadya [Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven, Heverlee 3001, Leuven, Belgium > > > >]
	Geris, Liesbet [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
	Vander Sloten, Jos [ > > ]
	Van Oosterwyck, Hans [ > > ]
Publication date :	2009
Main document title :	MICCAI 2009 Workshop Proceedings
Editor :	Miller, Karol
	Nielsen, Poul M.F.
Collection and collection volume :	Computational Biomechanics for Medicine IV
Pages :	87-97
Audience :	International
Event name :	International conference on medical image computing and computer assisted intervention
Event date :	20-24/9/2009
Event place (city) :	London
Event country :	UK
Keywords :	[en] Mathematical modeling ; Numerical simulation ; Blood platelet ; Bone regeneration ; Biomaterial ; Peri-implant endosseous healing
Abstract :	[en] Experimental investigations have demonstrated the importance of platelets and their activation for bone regeneration around oral implants. This study aimed to numerically demonstrate the key role of activated platelets which is controlled by implant surface characteristics. The cellular activities involved in the process of peri-implant endosseous healing can be represented by migration, proliferation, differentiation, removal, extracellular matrix synthesis and degradation, and growth factor production/release and decay. These activities are described by a system of highly coupled non-linear partial differential equations of taxis–diffusion–reaction type. Moreover, cell–biomaterial interactions were treated by including surface-specific model parameters. A well-designed in vivo model that looked at healing around oral implants with different surface properties was selected from literature to validate the results. Numerical simulations agreed well with the experimentally observed healing response and demonstrated that platelet-related model parameters, which were dependent on implant surface characteristics, modulate the pattern of healing.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/70870
Other URL :	http://school.mech.uwa.edu.au/CBM2009/CBM2009_proceedings.pdf

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