Reference : Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration around ...
Scientific congresses and symposiums : Paper published in a book
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Microbiology
Engineering, computing & technology : Computer science
Engineering, computing & technology : Mechanical engineering
Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration around Endosseous Oral Implants: In Silico Modeling
Amor, Nadya mailto [Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven, Heverlee 3001, Leuven, Belgium > > > >]
Geris, Liesbet mailto [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
Vander Sloten, Jos mailto [ > > ]
Van Oosterwyck, Hans mailto [ > > ]
MICCAI 2009 Workshop Proceedings
Miller, Karol
Nielsen, Poul M.F.
Computational Biomechanics for Medicine IV
International conference on medical image computing and computer assisted intervention
[en] Mathematical modeling ; Numerical simulation ; Blood platelet ; Bone regeneration ; Biomaterial ; Peri-implant endosseous healing
[en] Experimental investigations have demonstrated the importance of platelets and their activation for bone regeneration around oral implants. This study aimed to numerically demonstrate the key role of activated platelets which is controlled by implant surface characteristics. The cellular activities involved in the process of peri-implant endosseous healing can be represented by migration, proliferation, differentiation, removal, extracellular matrix synthesis and degradation, and growth factor production/release and decay. These activities are described by a system of highly coupled non-linear partial differential equations of taxis–diffusion–reaction type. Moreover, cell–biomaterial interactions were treated by including surface-specific model parameters. A well-designed in vivo model that looked at healing around oral implants with different surface properties was selected from literature to validate the results. Numerical simulations agreed well with the experimentally observed healing response and demonstrated that platelet-related model parameters, which were dependent on implant surface characteristics, modulate the pattern of healing.
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