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| Reference : Oxidative Stress in the Cochlea: An Update. |
| Scientific journals : Article | |||
| Life sciences : Anatomy (cytology, histology, embryology...) & physiology Human health sciences : Otolaryngology Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/70481 | |||
| Oxidative Stress in the Cochlea: An Update. | |
| English | |
| Poirrier, Anne-Lise [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >] | |
Pincemail, Joël  [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >] | |
| Van Den Ackerveken, P. [> > > >] | |
| Lefèbvre, Philippe [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >] | |
| Malgrange, Brigitte [Université de Liège - ULg > > GIGA - Neurosciences - Neurologie >] | |
| 2010 | |
| Current Medicinal Chemistry | |
| Bentham Science Publishers Ltd. | |
| 0929-8673 | |
| Schiphol | |
| The Netherlands | |
| [en] cochlea ; oxidative stress ; mammals | |
| [en] This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/70481 |
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