Reference : Oxidative Stress in the Cochlea: An Update.
Scientific journals : Article
Human health sciences : Otolaryngology
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Oxidative Stress in the Cochlea: An Update.
Poirrier, Anne-Lise [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]
Pincemail, Joël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Van Den Ackerveken, P. [> > > >]
Lefèbvre, Philippe mailto [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences - Neurologie >]
Current Medicinal Chemistry
Bentham Science Publishers Ltd.
Yes (verified by ORBi)
The Netherlands
[en] cochlea ; oxidative stress ; mammals
[en] This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.
Researchers ; Professionals

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