Reference : Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Otolaryngology
http://hdl.handle.net/2268/70477
Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10.
English
Breuskin, Ingrid [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]
Bodson, Morgan [Université de Liège - ULg > > Physiologie humaine et physiopathologie >]
Thelen, Nicolas mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Borgs, Laurence mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Stolt, Claus [> > > >]
Wegner, Michael [> > > >]
Lefèbvre, Philippe mailto [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences - Neurologie >]
2010
Journal of Neurochemistry
Blackwell Science
114
6
1827-39
Yes (verified by ORBi)
International
0022-3042
1471-4159
Oxford
United Kingdom
[en] cochlea ; inner ear ; sox10
[en] The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-binding domain transcription factor that is required for the proper development of neural crest cell derivatives, is specifically expressed in post-migratory neural crest cells in the cochleo-vestibular ganglion. Using Sox10-deficient mice, we demonstrate that this transcription factor is essential for the survival, but not the generation, of the post-migratory neural crest cells within the inner ear. In the absence of these neural crest-derived cells, we have investigated the survival of the otocyst-derived auditory neurons. Surprisingly, auditory neuron differentiation, sensory target innervation and survival are conserved despite the absence of glial cells. Moreover, brain-derived neurotrophic factor expression is increased in the hair cells of Sox10-deficient mice, a compensatory mechanism that may prevent spiral ganglion neuronal cell death. Taken together, these data suggest that in the absence of neural crest-derived glial cells, an increase trophic support from hair cells promotes the survival of spiral ganglion neurons in Sox10 mutant mice.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers ; Professionals
http://hdl.handle.net/2268/70477
also: http://hdl.handle.net/2268/74256
10.1111/j.1471-4159.2010.06897.x

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