ORBi: Poirrier Anne-Lise - Ototoxic drugs: difference in sensitivity between mice and guinea pigs.

Reference : Ototoxic drugs: difference in sensitivity between mice and guinea pigs.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biotechnology Life sciences : Biochemistry, biophysics & molecular biology Human health sciences : Otolaryngology
	To cite this reference:	http://hdl.handle.net/2268/70471

Title :	Ototoxic drugs: difference in sensitivity between mice and guinea pigs.
Language :	English
Author, co-author :	Poirrier, Anne-Lise [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]
	Van den Ackerveken, P. [> > > >]
	Kim, T. S. [> > > >]
	Vandenbosch, R. [> > > >]
	Nguyen, Laurent [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
	Lefèbvre, Philippe [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
	Malgrange, Brigitte [Université de Liège - ULg > > GIGA - Neurosciences - Neurologie >]
Publication date :	2010
Journal title :	Toxicology Letters
Publisher :	Elsevier
Volume :	193
Issue/season :	1
Pages :	41-9
Peer reviewed :	Yes (verified by ORBi)
ISSN :	0378-4274
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Animals ; Anti-Bacterial Agents/toxicity ; Antineoplastic Agents/toxicity ; Cisplatin/toxicity ; Deafness/chemically induced/pathology ; Drug Toxicity ; Evoked Potentials, Auditory, Brain Stem/drug effects ; Fluorescent Antibody Technique ; Guinea Pigs ; Hearing/drug effects ; Kanamycin/toxicity ; Male ; Mice ; Mice, Inbred BALB C ; Neurons/pathology ; Organ of Corti/pathology ; Species Specificity ; Spiral Ganglion/drug effects/pathology ; Tolonium Chloride
Abstract :	[en] The development of experimental animal models has played an invaluable role in understanding the mechanisms of neurosensory deafness and in devising effective treatments. The purpose of this study was to develop an adult mouse model of ototoxic drug-induced hearing loss and to compare the ototoxicity in the adult mouse to that in the well-described guinea pig model. Mice are a powerful model organism, especially due to the large availability of antibodies, probes and genetic mutants. In this study, mice (n=114) and guinea pigs (n=35) underwent systemic treatment with either kanamycin or cisplatin. Auditory brainstem responses showed a significant threshold shift in guinea pigs 2 weeks after the beginning of the ototoxic treatment, while there was no significant hearing impairment recorded in mice. Hair cells and neuronal loss were correlated with hearing function in both guinea pigs and mice. These results indicate that the mouse is not a good model for ototoxicity, which should be taken into consideration in all further investigations concerning ototoxicity-induced hearing loss.
Research units :	Giga-Neurosciences
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/70471
DOI :	10.1016/j.toxlet.2009.12.003

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