Reference : Connecting biology and mechanics in fracture healing: an integrated mathematical modelin...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Engineering, computing & technology : Mechanical engineering
http://hdl.handle.net/2268/70341
Connecting biology and mechanics in fracture healing: an integrated mathematical modeling framework for the study of nonunions
English
Geris, Liesbet mailto [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
Vander Sloten, Jos mailto [Division of Biomechanics and Engineering Design, K.U. Leuven, Celestijnenlaan 300C (2419), 3001 Leuven, Belgium > > > >]
Van Oosterwyck, Hans mailto [Division of Biomechanics and Engineering Design, K.U. Leuven, Celestijnenlaan 300C (2419), 3001 Leuven, Belgium > > > >]
Mar-2010
Biomechanics & Modeling in Mechanobiology
Springer Science & Business Media B.V.
9
6
713-724
Yes (verified by ORBi)
International
1617-7959
1617-7940
[en] Mathematical modeling ; Mechanobiology ; Angiogenesis ; Osteogenesis ; Fracture healing
[en] Both mechanical and biological factors play an important role in normal as well as impaired fracture healing. This study aims to provide a mathematical framework in which both regulatory mechanisms are included. Mechanics and biology are coupled by making certain parameters of a previously established bioregulatory model dependent on local mechanical stimuli. To illustrate the potential added value of such a framework, this coupled model was applied to investigate whether local mechanical stimuli influencing only the angiogenic process can explain normal healing as well as overload-induced nonunion development. Simulation results showed that mechanics acting directly on angiogenesis alone was not able to predict the formation of overload-induced onunions. However, the direct action of mechanics on both angiogenesis and osteogenesis was able to predict overload-induced nonunion formation, confirming
the hypotheses of several experimental studies investigating the interconnection between angiogenesis and osteogenesis. This study shows that mathematical models can assist in testing hypothesis on the nature of the interaction between biology
and mechanics.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/70341
10.1007/s10237-010-0208-8

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