You are here:
| Reference : Connecting biology and mechanics in fracture healing: an integrated mathematical modelin... |
| Scientific journals : Article | |||
| Engineering, computing & technology : Mechanical engineering Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/70341 | |||
| Connecting biology and mechanics in fracture healing: an integrated mathematical modeling framework for the study of nonunions | |
| English | |
Geris, Liesbet  [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >] | |
| Vander Sloten, Jos [Division of Biomechanics and Engineering Design, K.U. Leuven, Celestijnenlaan 300C (2419), 3001 Leuven, Belgium > > > >] | |
| Van Oosterwyck, Hans [Division of Biomechanics and Engineering Design, K.U. Leuven, Celestijnenlaan 300C (2419), 3001 Leuven, Belgium > > > >] | |
| Mar-2010 | |
| Biomechanics & Modeling in Mechanobiology | |
| Springer Science & Business Media B.V. | |
| 9 | |
| 6 | |
| 713-724 | |
| Yes (verified by ORBi) | |
| International | |
| 1617-7959 | |
| 1617-7940 | |
| [en] Mathematical modeling ; Mechanobiology ; Angiogenesis ; Osteogenesis ; Fracture healing | |
| [en] Both mechanical and biological factors play an important role in normal as well as impaired fracture healing. This study aims to provide a mathematical framework in which both regulatory mechanisms are included. Mechanics and biology are coupled by making certain parameters of a previously established bioregulatory model dependent on local mechanical stimuli. To illustrate the potential added value of such a framework, this coupled model was applied to investigate whether local mechanical stimuli influencing only the angiogenic process can explain normal healing as well as overload-induced nonunion development. Simulation results showed that mechanics acting directly on angiogenesis alone was not able to predict the formation of overload-induced onunions. However, the direct action of mechanics on both angiogenesis and osteogenesis was able to predict overload-induced nonunion formation, confirming
the hypotheses of several experimental studies investigating the interconnection between angiogenesis and osteogenesis. This study shows that mathematical models can assist in testing hypothesis on the nature of the interaction between biology and mechanics. | |
| Researchers ; Professionals ; Students | |
| http://hdl.handle.net/2268/70341 | |
| 10.1007/s10237-010-0208-8 |
| File(s) associated to this reference | ||||||||||||||
|
Fulltext file(s):
| ||||||||||||||
All documents in ORBi are protected by a user license.
