ORBi: Geris Liesbet - Numerical simulation of bone regeneration in a bone chamber.

Reference : Numerical simulation of bone regeneration in a bone chamber.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Microbiology Engineering, computing & technology : Computer science
	To cite this reference:	http://hdl.handle.net/2268/70334

Title :	Numerical simulation of bone regeneration in a bone chamber.
Language :	English
Author, co-author :	Geris, Liesbet [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
	Vandamme, K. [>2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven > > > >]
	Naert, I. [>2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven > > > >]
	Vander Sloten, J. [>1Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C—PB 2419, 3001 Leuven, Belgium > > > > > >]
	Duyck, J. [>2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven > > > > > >]
	Van Oosterwyck, H. [>1Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C—PB 2419, 3001 Leuven, Belgium > > > > > >]
Publication date :	2009
Journal title :	Journal of Dental Research
Publisher :	International & American Associations for Dental Research
Volume :	88
Issue/season :	2
Pages :	158-63
Audience :	International
ISSN :	0022-0345
e-ISSN :	1544-0591
City :	Alexandria
Country :	VA
Keywords :	[en] Animals ; Computer Simulation ; Dental Implants ; Dental Restoration Failure ; Dental Stress Analysis ; Finite Element Analysis ; Implants, Experimental ; Models, Biological ; Numerical Analysis, Computer-Assisted ; Osseointegration/physiology ; Rabbits ; Tibia/surgery
Abstract :	[en] While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains uninvestigated. We tested the hypothesis that a mechano-regulatory model has the potential to predict bone regeneration around implants. In an in vivo bone chamber set-up allowing for controlled implant loading (up to 90 microm axial displacement), bone tissue formation was simulated and compared qualitatively and quantitatively with histology. Furthermore, the model was applied to simulate excessive loading conditions. Corresponding to literature data, implant displacement magnitudes larger than 90 microm predicted the formation of fibrous tissue encapsulation of the implant. In contradiction to findings in orthopedic implant osseointegration, implant displacement frequencies higher than 1 Hz did not favor the formation of peri-implant bone in the chamber. Additional bone chamber experiments are needed to test these numerical predictions.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/70334
DOI :	10.1177/0022034508329603

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