Reference : Numerical simulation of bone regeneration in a bone chamber.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Microbiology
Engineering, computing & technology : Computer science
http://hdl.handle.net/2268/70334
Numerical simulation of bone regeneration in a bone chamber.
English
Geris, Liesbet mailto [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
Vandamme, K. [>2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven > > > >]
Naert, I. [>2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven > > > >]
Vander Sloten, J. [>1Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C—PB 2419, 3001 Leuven, Belgium > > > > > >]
Duyck, J. [>2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven > > > > > >]
Van Oosterwyck, H. [>1Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C—PB 2419, 3001 Leuven, Belgium > > > > > >]
2009
Journal of Dental Research
International & American Associations for Dental Research
88
2
158-63
Yes (verified by ORBi)
International
0022-0345
1544-0591
Alexandria
VA
[en] Animals ; Computer Simulation ; Dental Implants ; Dental Restoration Failure ; Dental Stress Analysis ; Finite Element Analysis ; Implants, Experimental ; Models, Biological ; Numerical Analysis, Computer-Assisted ; Osseointegration/physiology ; Rabbits ; Tibia/surgery
[en] While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains uninvestigated. We tested the hypothesis that a mechano-regulatory model has the potential to predict bone regeneration around implants. In an in vivo bone chamber set-up allowing for controlled implant loading (up to 90 microm axial displacement), bone tissue formation was simulated and compared qualitatively and quantitatively with histology. Furthermore, the model was applied to simulate excessive loading conditions. Corresponding to literature data, implant displacement magnitudes larger than 90 microm predicted the formation of fibrous tissue encapsulation of the implant. In contradiction to findings in orthopedic implant osseointegration, implant displacement frequencies higher than 1 Hz did not favor the formation of peri-implant bone in the chamber. Additional bone chamber experiments are needed to test these numerical predictions.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/70334
10.1177/0022034508329603

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