[en] While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains uninvestigated. We tested the hypothesis that a mechano-regulatory model has the potential to predict bone regeneration around implants. In an in vivo bone chamber set-up allowing for controlled implant loading (up to 90 microm axial displacement), bone tissue formation was simulated and compared qualitatively and quantitatively with histology. Furthermore, the model was applied to simulate excessive loading conditions. Corresponding to literature data, implant displacement magnitudes larger than 90 microm predicted the formation of fibrous tissue encapsulation of the implant. In contradiction to findings in orthopedic implant osseointegration, implant displacement frequencies higher than 1 Hz did not favor the formation of peri-implant bone in the chamber. Additional bone chamber experiments are needed to test these numerical predictions.
Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Vandamme, K.; 2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven
Naert, I.; 2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven
Vander Sloten, Jos; 1Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C—PB 2419, 3001 Leuven, Belgium
Duyck, J.; 2Department of Prosthetic Dentistry/BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K.U. Leuven
Van Oosterwyck, H.; 1Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C—PB 2419, 3001 Leuven, Belgium
Language :
English
Title :
Numerical simulation of bone regeneration in a bone chamber.
Publication date :
2009
Journal title :
Journal of Dental Research
ISSN :
0022-0345
eISSN :
1544-0591
Publisher :
International & American Associations for Dental Research, Alexandria, United States - Virginia
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