ORBi: Geris Liesbet - Mathematical modeling of fracture healing: coupling between mechanics, angiogenesis and osteogenesis

Reference : Mathematical modeling of fracture healing: coupling between mechanics, angiogenesis and ...


	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Microbiology
	To cite this reference:	http://hdl.handle.net/2268/70328

Title :	Mathematical modeling of fracture healing: coupling between mechanics, angiogenesis and osteogenesis
Language :	English
Author, co-author :	Geris, Liesbet [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
	Vander Sloten, Jos [ > > ]
	VanOosterwyck, Hans [ > > ]
Publication date :	2008
Main document title :	IFMBE Proceedings 22
Publisher :	Springer-Verlag
Collection and collection volume :	Volume 22, Part 22
Pages :	2651-2654
Peer reviewed :	Yes
Audience :	International
City :	Berlin Heidelberg
Event name :	4th European Conference of the International Federation for Medical and Biological Engineering
Event date :	23-27/11/2008
Event place (city) :	Antwerp
Event country :	Belgium
Keywords :	[en] Mechanobiology ; Mathematical Modeling ; Fracture Healing ; Angiogenesis
Abstract :	[en] Both mechanical and biological factors play an important role in normal as well as impaired fracture healing. This study aims to provide a mathematical framework in which both regulatory mechanisms are included and angiogenesis is explicitly incorporated. To illustrate the added value of such a framework, a coupled mechanobioregulatory model was proposed. This model was based on a previously developed bioregulatory model [1], using a simple coupling between mechanics and biology whereby certain parameters of the bioregulatory model were made dependent on local mechanical stimuli. As a first example, in this study, the proliferation of osteoblasts and endothelial cells were made dependent on the local fluid flow [2]. Various loading situations, ranging from non-loading to overloading, were simulated. Simulations of adverse mechanical circumstances predicted the formation of avascular nonunions, a result that was corroborated by various experimental observations. This model allows testing various hypotheses concerning the nature of the mechanical stimulus influencing the healing process, as well as the most important cellular processes influenced by mechanical loading. It is one of the first models that provides an explicit coupling between mechanical and angiogenic factors. As both factors have been identified to play a key role in the occurrence of delayed and nonunions, the model allows to further explore their etiology and treatment.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/70328
DOI :	10.1007/978-3-540-89208-3_636

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Mathematical modeling of fracture healing.pdf		Publisher postprint	226.17 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5