[en] OBJECTIVE: The aim of this study was to evaluate the effect of various degrees of implant displacement on the tissue differentiation around immediately loaded cylindrical turned titanium implants. DESIGN: The experiments were conducted in repeated sampling bone chambers placed in the tibia of 10 rabbits. Tissues could grow into the bone chambers via perforations. Due to its double structure, tissues inside the chamber could be harvested leaving the chamber intact. This allowed several experiments within the same animal. The chambers contained a cylindrical turned titanium implant that was loaded in a well-controlled manner. In each of the 10 chambers, four experiments were conducted with the following test conditions: immediate implant loading by inducing 0 (control), 30, 60 and 90 microm implant displacement, 800 cycles per day at a frequency of 1 Hz, twice a week during a period of 6 weeks. Histological and histomorphometrical analyses were performed on methylmethacrylate histological sections. An ANOVA was conducted on the dataset. RESULTS: The total tissue volume was significantly lowest in the unloaded control condition. The bone volume fraction on the other hand, was significantly larger in the unloaded and 90 microm implant displacement, compared to the 30 microm implant displacement. Bone density increased with increasing micro-motion with significantly higher values for the 60 microm- and 90 microm-test conditions compared to the unloaded situation. The chance to have bone-to-implant contact decreased in case of micro-motion at the tissues-implant interface. CONCLUSION: The magnitude of implant displacement had a statistically significant effect on the tissue differentiation around immediately loaded cylindrical turned titanium implants. Implant micro-motion had a detrimental effect on the bone-to-implant contact in an immediate loading regimen.
Disciplines :
Surgery Computer science Microbiology Biochemistry, biophysics & molecular biology
Author, co-author :
Duyck, Joke; Department of Prosthetic Dentistry, BIOMAT Research Group, Catholic University of Leuven, Kapucijnenvoer 7, B-3000 Leuven, Belgium
Vandamme, K.; Department of Prosthetic Dentistry, BIOMAT Research Group, Catholic University of Leuven, Kapucijnenvoer 7, B-3000 Leuven, Belgium
Geris, Liesbet ; Department of Mechanical Engineering, Division of Biomechanics and Engineering Design, Catholic University of Leuven, Celestijnenlaan 100A, B-3001 Heverlee, Belgium
Van Oosterwyck, H.; Department of Mechanical Engineering, Division of Biomechanics and Engineering Design, Catholic University of Leuven, Celestijnenlaan 100A, B-3001 Heverlee, Belgium
De Cooman, M.; Department of Electrotechnics, ESAT-MICAS, Catholic University of Leuven, Kasteelpark Arenberg 10, B-3001 Heverlee, Belgium
Vandersloten, J.; Department of Mechanical Engineering, Division of Biomechanics and Engineering Design, Catholic University of Leuven, Celestijnenlaan 100A, B-3001 Heverlee, Belgium
Puers, R.; Department of Electrotechnics, ESAT-MICAS, Catholic University of Leuven, Kasteelpark Arenberg 10, B-3001 Heverlee, Belgium
Naert, I.; Department of Prosthetic Dentistry, BIOMAT Research Group, Catholic University of Leuven, Kapucijnenvoer 7, B-3000 Leuven, Belgium
Language :
English
Title :
The influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants.
P.I. Brånemark, R. Adell, U. Breine, B.O. Hansson, J. Lindstrom, and A. Ohlsson Intra-osseous anchorage of dental prostheses. I. Experimental studies Scand J Plast Reconstr Surg 3 1969 81 100
P.I. Brånemark, P. Engstrand, L.O. Ohrnell, K. Grondahl, P. Nilsson, and K. Hagberg Brånemark Novum: a new treatment concept for rehabilitation of the edentulous mandible. Preliminary results from a prospective clinical follow-up study Clin Implant Dent Relat Res 1 1999 2 16
K. Randow, I. Ericsson, K. Nilner, A. Petersson, and P.O. Glantz Immediate functional loading of Brånemark dental implants: an 18-month clinical follow-up study Clin Oral Implants Res 10 1999 8 15
I. Ericsson, K. Randow, K. Nilner, and A. Peterson Early functional loading of Brånemark dental implants: 5-year clinical follow-up study Clin Implant Dent Relat Res 2 2000 70 77
C. Gatti, W. Haefliger, and M. Chiapasco Implant-related mandibular overdentures with immediate loading: a prospective study of ITI implants Int J Oral Maxillofac Impl 15 2000 383 388
K. Horiuchi, H. Uchida, K. Yamamoto, and M. Sugimura Immediate loading of Brånemark system implants following placement in edentulous patients : a clinical resport Int J Oral Maxillofac Implants 15 2000 824 830
R.A. Jaffin, A. Kumar, and C.L. Berman Immediate loading of implants in partially and fully edentulous jaws : a series of 27 case reports J Periodontol 71 2000 833 838
P. Malo, B. Rangert, and L. Dvarsater Immediate function of Brånemark implants in the esthetic zone: a retrospective clinical study with 6 months to 4 years of follow-up Clin Implant Dent Relat Res 2 2000 138 146
L.E. Colomina Immediate loading of implant-fixed mandibular prostheses: a prospective 18-month follow-up clinical study - preliminary report Implant Dent 10 2001 23 29
G. Romanos, C.G. Toh, C.H. Siar, D. Swaminathan, A.H. Ong, and K. Donath Peri-implant bone reactions to immediately loaded implants. An experimental study in monkeys J Periodontol 72 2001 506 511
C. Aparicio, B. Rangert, and L. Sennerby Immediate/early loading of dental implants: a report from the Sociedad Espanola de Implantes World Congress consensus meeting in Barcelona, Spain, 2002 Clin Implant Dent Relat Res 5 2003 57 60
C.E. Misch, and M. Degidi Five-year prospective study of immediate/early loading of fixed prostheses in completely edentulous jaws with a bone quality-based implant system Clin Implant Dent Relat Res 5 2003 17 28
G. Cannizzaro, and M. Leone Restoration of partially edentulous patients using dental implants with a microtextured surface: a prospective comparison of delayed and immediate full occlusal loading Int J Oral Maxillofac Implants 18 2003 512 522
M. Degidi, A. Scarano, G. Iezzi, and A. Piattelli Periimplant bone in immediately loaded titanium implants: histologic and histomorphometric evaluation in human. A report of two cases Clin Implant Dent Relat Res 5 2003 170 175
T. Albrektsson, P.I. Brånemark, H.A. Hansson, and J. Lindstrøm Osseointegrated titanium implants: requirements for ensuring a long-lasting, direct bone to implant anchorage in man Acta Orthop Scand 52 1981 155 170
T. Albrektsson, T. Hansson, and T. Lekholm Osseointegrated dental implants Dent Clin North Am 30 1986 151 174
T.J. Balshi, and G.J. Wolfinger Immediate loading of Brånemark implants in edentulous mandibles: a preliminary report Implants Dent 5 1997 83 88
P. Engstrand, K. Grondahl, L.O. Ohrnell, P. Nilsson, U. Nannmark, and P.I. Branemark Prospective follow-up study of 95 patients with edentulous mandibles treated according to the Brånemark Novum concept Clin Implant Dent Relat Res 5 2003 3 10
R.M. Pilliar, J.M. Lee, and C. Maniatopoulos Observations on the effect of movement on bone ingrowth into porous-surfaced implants Clin Orthop 208 1986 108 113
S. Szmukler-Moncler, H. Salama, Y. Reingewirtz, and J.H. Dubruille Timing of loading and effect of micromotion on bone-dental implant interface: review of the experimental literature J Biomed Mater Res 43 1998 192 203
R. Gapski, H.L. Wang, P. Mascarenhas, and N. Lang Critical review of immediate implant loading Clin Oral Implants Res 14 2003 515 527
H. Cameron, R.M. Pilliar, and I. Macnab The effect of movement on the bonding of porous metal to bone J Biomed Mater Res 7 1973 301 311
C. Maniatopoulos, R.M. Pilliar, and D.C. Smith Threaded versus porous-surfaced designs for implant stabilization in bone-endodontic implant model J Biomed Mater Res 20 1986 1309 1333
K. Søballe, E.S. Hansen, H. Brockstedt-Rasmussen, and C. Bünger Tissue ingrowth into titanium and hydroxyapatite coated implants during stable and unstable mechanical conditions J Orthopaed Res 10 1992 285 299
K. Søballe, and E.S. Hansen Brockstedt-Rasmussen H, Bünger C. The effects of steoporosis, bone deficiencey, bone grafting and micromotion on fixation of porous-coated hydroxyapatite-coated implants R.G.T. Geesink M.T. Manley Hydroxyapatiet Coatings in Orthopaedic Surgery 1993 Raven Press New York 107 136
J. Duyck, M. De Cooman, R. Puers, H. Van Oosterwyck, and J. Vander Sloten A repeated sampling bone chamber methodology for the evaluation of tissue differentiation and bone adaptation around titanium implants under controlled mechanical conditions J Biomech 37 2004 1819 1822
H.M. Frost Bone "mass" and the "mechanostat". A proposal Anat Rec 219 1987 1 9
C.H. Turner Three rules for bone adaptation to mechanical stimuli Bone 23 1998 399 407
S. Kiliardis, A. Bresin, J. Holm, and K.G. Strid Effects of masticatory muscle function on bone mass in the mandible of the growing rat Acta Anat 155 1996 200 205
A. Bresin, S. Kiliardis, and K.G. Strid Effects of masticatory function on the internal bone structure in the mandible of the growing rat Eur J Oral Sci 107 1999 35 44
E.B.W. Giesen, M. Ding, M. Dalstra, and T.M.G.J. van Eijden Reduced mechanical load decreases the density, the stiffness, and strength of cancellous bone of the mandibular condyle Clin Biomech 18 2003 358 363
Wennerberg A. On surface roughness and implant incorporation, PhD Thesis, Göteborg, 1996, p. 62.
A. Piatelli, M. Corigliano, A. Scarano, G. Costigliola, and M. Paolantonio Immediate loading of titanium plasma-sprayed implants: an histologic analysis in monkeys J Periodontol 69 1998 321 327
U. Meyer, U. Joos, J. Mythili, T. Stamm, A. Hohoff, and T. Fillies Ultrastructural characterization of the implant/bone interface of immediately loaded dental implants Biomaterials 24 2004 1959 1967
E. Nkenke, B. Lehner, K. Weinzierl, U. Thams, J. Neugebauer, and H. Steveling Bone contact, growth, and density around immediately loaded implants in the mandible of mini-pigs Clin Oral Implants Res 14 2003 312 321
H.W.A. Wiskott, and U.C. Belser Lack of osseointegration of smooth titanium surfaces: a working hypothesis based on strains generated in the surrounding bone Clin Oral Implants Res 10 1999 429 444
