Reference : Numerical simulation of tissue differentiation around loaded titanium implants in a b...
Scientific journals : Article
Life sciences : Microbiology
Human health sciences : Surgery
Engineering, computing & technology : Computer science
http://hdl.handle.net/2268/70311
Numerical simulation of tissue differentiation around loaded titanium implants in a bone chamber.
English
Geris, Liesbet mailto [Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium > > > >]
Andreykiv, A. [Faculty of Design, Engineering and Production, Delft University of Technology, Mekelweg 2, Delft 2628 CD, The Netherlands > > > > > >]
Van Oosterwyck, H. [Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium > > > > > >]
Sloten, J Vander [Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium > > > > > >]
van Keulen, F. [Faculty of Design, Engineering and Production, Delft University of Technology, Mekelweg 2, Delft 2628 CD, The Netherlands > > > > > >]
Duyck, J. [Department of Prosthetic Dentistry, Faculty of Medicine, Katholieke Univeriteit Leuven, Kapucijnenvoer 7, Leuven B-3000, Belgium > > > > > >]
Naert, I. [Department of Prosthetic Dentistry, Faculty of Medicine, Katholieke Univeriteit Leuven, Kapucijnenvoer 7, Leuven B-3000, Belgium > > > > > >]
2004
Journal of Biomechanics
Elsevier Science
37
5
763-9
Yes (verified by ORBi)
International
0021-9290
New York
NY
[en] Animals ; Cell Differentiation/physiology ; Computer Simulation ; Culture Techniques/methods ; Implants, Experimental ; Mechanotransduction, Cellular/physiology ; Models, Biological ; Rabbits ; Tibia/cytology/physiology ; Titanium
[en] The application of a bone chamber provides a controlled environment for the study of tissue differentiation and bone adaptation. The influence of different mechanical and biological factors on the processes can be measured experimentally. The goal of the present work is to numerically model the process of peri-implant tissue differentiation inside a bone chamber, placed in a rabbit tibia. 2D and 3D models were created of the tissue inside the chamber. A number of loading conditions, corresponding to those applied in the rabbit experiments, were simulated. Fluid velocity and maximal distortional strain were considered as the stimuli that guide the differentiation process of mesenchymal cells into fibroblasts, chondrocytes and osteoblasts. Mesenchymal cells migrate through the chamber from the perforations in the chamber wall. This process is modelled by the diffusion equation. The predicted tissue phenotypes as well as the process of tissue ingrowth into the chamber show a qualitative agreement with the results of the rabbit experiments. Due to the limited number of animal experiments (four) and the observed inter-animal differences, no quantitative comparison could be made. These results however are a strong indication of the feasibility of the implemented theory to predict the mechano-regulation of the differentiation process inside the bone chamber.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/70311
10.1016/j.jbiomech.2003.09.026

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