[en] The application of a bone chamber provides a controlled environment for the study of tissue differentiation and bone adaptation. The influence of different mechanical and biological factors on the processes can be measured experimentally. The goal of the present work is to numerically model the process of peri-implant tissue differentiation inside a bone chamber, placed in a rabbit tibia. 2D and 3D models were created of the tissue inside the chamber. A number of loading conditions, corresponding to those applied in the rabbit experiments, were simulated. Fluid velocity and maximal distortional strain were considered as the stimuli that guide the differentiation process of mesenchymal cells into fibroblasts, chondrocytes and osteoblasts. Mesenchymal cells migrate through the chamber from the perforations in the chamber wall. This process is modelled by the diffusion equation. The predicted tissue phenotypes as well as the process of tissue ingrowth into the chamber show a qualitative agreement with the results of the rabbit experiments. Due to the limited number of animal experiments (four) and the observed inter-animal differences, no quantitative comparison could be made. These results however are a strong indication of the feasibility of the implemented theory to predict the mechano-regulation of the differentiation process inside the bone chamber.
Disciplines :
Microbiology Surgery Computer science
Author, co-author :
Geris, Liesbet ; Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium
Andreykiv, Andriy; Faculty of Design, Engineering and Production, Delft University of Technology, Mekelweg 2, Delft 2628 CD, The Netherlands
Van Oosterwyck, Hans V.; Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium
Vander Sloten, Jos; Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium
van Keulen, F.; Faculty of Design, Engineering and Production, Delft University of Technology, Mekelweg 2, Delft 2628 CD, The Netherlands
Duyck, J.; Department of Prosthetic Dentistry, Faculty of Medicine, Katholieke Univeriteit Leuven, Kapucijnenvoer 7, Leuven B-3000, Belgium
Naert, I.; Department of Prosthetic Dentistry, Faculty of Medicine, Katholieke Univeriteit Leuven, Kapucijnenvoer 7, Leuven B-3000, Belgium
Language :
English
Title :
Numerical simulation of tissue differentiation around loaded titanium implants in a bone chamber.
Publication date :
2004
Journal title :
Journal of Biomechanics
ISSN :
0021-9290
eISSN :
1873-2380
Publisher :
Elsevier Science, New York, United States - New York
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